The prognostic value of G8 for functional decline
| dc.rights.license | open | en_US |
| dc.contributor.author | CHAKIBA, C. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BELLERA, Carine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ETCHEPARE, Fanny | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MATHOULIN-PELISSIER, Simone | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | RAINFRAY, Muriel | |
| dc.contributor.author | SOUBEYRAN, P. | |
| dc.date.accessioned | 2020-06-04T08:51:36Z | |
| dc.date.available | 2020-06-04T08:51:36Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 1879-4076 (Electronic) 1879-4068 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/7741 | |
| dc.description.abstractEn | PURPOSE: Clinical experience suggests that functional decline (FD) during treatment may have a major adverse impact on outcome. Geriatric assessment of older patients before cancer treatment is usually based on use of a screening tool (such as G8) followed by comprehensive geriatric assessment (CGA). However, many oncology teams cannot implement geriatric oncology management due to non-availability of geriatricians. Consequently, we decided to evaluate whether a procedure using G8 and routinely available factors could help oncologists foresee the outcome in patients >/=70: we firstly evaluated whether functional decline is a determinant of early death, then searched for predictors of early functional decline (measured before initiation of the second cycle of chemotherapy), including G8 but voluntarilly excluding CGA. METHODS: We tested the value of clinical, biological factors and early FD to predict early death on a cohort of 292 patients (>/=70years) treated with first-line chemotherapy. We then used a logistic regression model to search for pretreatment predictors of FD, including the same factors and G8 but excluding CGA. RESULTS: FD occurred in 48 patients. In multivariate analyses, early FD (OR=4.13, 95% CI [1.89; 9.04], p<.01), disease extension (OR=4.55, 95% CI [1.96; 10.57]; p<.01), and being male (OR=2.59, 95% CI [1.12; 5.97], p =.02) were significant prognostic factors for early death; G8 was the only significant factor associated with FD (OR=4.38, 95% CI [1.28; 14.92], p=.018). CONCLUSIONS: FD has an important prognostic significance in patients >/=70 treated with chemotherapy, and G8 predicts for its occurrence. These data reinforce the routine use of G8 in the management of these patients. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | EPICENE | |
| dc.title.en | The prognostic value of G8 for functional decline | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.jgo.2018.12.004 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 30638869 | en_US |
| bordeaux.journal | Journal of Geriatric Oncology | en_US |
| bordeaux.page | 921-925 | en_US |
| bordeaux.volume | 10 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 6 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | EPICENE_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03212192 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-04-29T11:57:57Z | |
| hal.export | true | |
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