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Screening of esophageal varices in children using esophageal capsule endoscopy: a multicenter prospective study

dc.rights.licenseopenen_US
dc.contributor.authorCARDEY, J.
dc.contributor.authorLE GALL, C.
dc.contributor.authorMICHAUD, L.
dc.contributor.authorDABADIE, A.
dc.contributor.authorTALBOTEC, C.
dc.contributor.authorBELLAICHE, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLAMIREAU, Thierry
dc.contributor.authorMAS, E.
dc.contributor.authorBRIDOUX-HENNO, L.
dc.contributor.authorVIALA, J.
dc.contributor.authorRESTIER-MIRON, L.
dc.contributor.authorLACHAUX, A.
dc.date.accessioned2020-06-03T14:00:37Z
dc.date.available2020-06-03T14:00:37Z
dc.date.issued2019
dc.identifier.issn1438-8812 (Electronic) 0013-726X (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7727
dc.description.abstractEnBACKGROUND: Esophagogastroduodenoscopy (EGD) is the standard method for diagnosis of esophageal and gastric varices in children. In this prospective study we evaluated the use of PillCam esophageal capsule endoscopy (ECE) in pediatric patients. METHODS: Patients aged 7 to 18 years presenting with portal hypertension and/or cirrhosis underwent ECE (PillCam ESO 2, Given Imaging Ltd.) followed by EGD. RESULTS: 102 patients were screened, 81 (52 boys; mean age 13.96 +/- 0.25 years) were included and 21 were excluded (16 for "candy test" failure). Esophageal varices were identified by EGD in 62 patients (77 %) and by ECE in 57 patients (70 %) using the de Franchis classification (DFC). The sensitivity of ECE for esophageal varices was 92 % and the specificity was 100 % using DFC. Based upon 57/81 patients with small, medium, and large varices on both ECE and EGD, using DFC, the sensitivity, specificity, positive (PPV) and negative predictive value (NPV) were 55 %, 92 %, 89 %, and 63 %, respectively, giving a total overall accuracy of 72 %. To improve sensitivity and specificity in classification of esophageal varices, we propose using a modified score. This score detected esophageal varices with 100 % sensitivity, 93 % specificity, 94 % PPV, and 100 % NPV, giving a total overall accuracy of 97 %. All patients preferred ECE over EGD. No capsule retention was recorded. CONCLUSIONS: ECE is a well-tolerated and safe procedure in children. Using the modified score, the sensitivity of ECE is currently sufficient to detect esophageal varices and replace EGD in infants with suspicion of esophageal varices or when EGD is refused.
dc.language.isoENen_US
dc.subject.enLEHA
dc.title.enScreening of esophageal varices in children using esophageal capsule endoscopy: a multicenter prospective study
dc.title.alternativeEndoscopyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1055/a-0647-1709en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30184608en_US
bordeaux.journalEndoscopyen_US
bordeaux.page10-17en_US
bordeaux.volume51en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Endoscopy&rft.date=2019&rft.volume=51&rft.issue=1&rft.spage=10-17&rft.epage=10-17&rft.eissn=1438-8812%20(Electronic)%200013-726X%20(Linking)&rft.issn=1438-8812%20(Electronic)%200013-726X%20(Linking)&rft.au=CARDEY,%20J.&LE%20GALL,%20C.&MICHAUD,%20L.&DABADIE,%20A.&TALBOTEC,%20C.&rft.genre=article


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