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Effect of hepatitis B virus (HBV) surface-gene variability on markers of replication during treated human immunodeficiency virus-HBV infection in Western Africa

dc.rights.licenseopenen_US
dc.contributor.authorBOYD, A.
dc.contributor.authorMOH, Desmorys Raoul
dc.contributor.authorMAYLIN, S.
dc.contributor.authorABDOU CHEKARAOU, M.
dc.contributor.authorMAHJOUB, N.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGABILLARD, Delphine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorANGLARET, Xavier
dc.contributor.authorEHOLIE, S. P.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDANEL, Christine
dc.contributor.authorDELAUGERRE, C.
dc.contributor.authorZOULIM, F.
dc.contributor.authorLACOMBE, K.
dc.date.accessioned2020-06-03T12:08:17Z
dc.date.available2020-06-03T12:08:17Z
dc.date.issued2019
dc.identifier.issn1478-3231 (Electronic) 1478-3223 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7720
dc.description.abstractEnBACKGROUND & AIMS: Replication markers exhibit substantial variation during chronic hepatitis B virus (HBV) infection, part of which can be explained by mutations on the surface (S) gene. We aimed to identify S-gene mutations possibly influencing the quantification of HBV replication markers (MUPIQH) in HBV genotype E infection, common to Western Africa. METHODS: 73 antiretroviral treatment (ART)-naive human immunodeficiency virus (HIV)-HBV co-infected patients from Cote d'Ivoire, initiating anti-HBV-containing ART, had available HBV S-gene sequences. S-gene MUPIQHs were screened at ART-initiation based on lower HBV-DNA or HBsAg quantification (qHBsAg) compared to wildtype. Their association with HBV virological response and qHBsAg slope during treatment was evaluated. RESULTS: Genotype E was predominant (95.9%). At ART-initiation, median HBV-DNA was 7.27 log10 copies/mL (IQR=5.26-8.33) and qHBsAg 4.08 log10 IU/mL (IQR=3.49-4.61). Twelve S-gene MUPIQHs were identified among 21 patients (28.8%): sS140L (n=4), sD144A (n=1), sS167L (n=2), sS174N (n=6), sP178Q (n=2), sG185L (n=2), sW191L (n=2), sP203Q/R (n=2), sS204N/I/R/K/T/G (n=7), sN207T (n=2), sF212C (n=1) and sV224A/Y (n=7). MUPIQHs at positions s185+s191+s224 and s178+s204 were within highly-covarying networks of S-gene mutations. Older age (p=0.02), elevated transaminases (p=0.03), and anti-hepatitis B "e" antibody-positive serology (p=0.009) were significantly associated with prevalent MUPIQHs at ART-initiation. During treatment, baseline MUPIQHs were not associated with time-to-undetectable HBV-DNA (p=0.7) and qHBsAg levels decreased at similar rates between those with versus without MUPIQHs (p=0.5). CONCLUSION: Several novel S-gene mutations were associated with reductions in replication markers among West African co-infected patients. These mutations, however, do not affect response during antiviral treatment. Their diagnostic and clinical consequences need clarification. This article is protected by copyright. All rights reserved.
dc.language.isoENen_US
dc.subject.enIDLIC
dc.title.enEffect of hepatitis B virus (HBV) surface-gene variability on markers of replication during treated human immunodeficiency virus-HBV infection in Western Africa
dc.title.alternativeLiver Inten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/liv.13975en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30257068en_US
bordeaux.journalLiver internationalen_US
bordeaux.page280-289en_US
bordeaux.volume39en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Liver%20international&rft.date=2019&rft.volume=39&rft.issue=2&rft.spage=280-289&rft.epage=280-289&rft.eissn=1478-3231%20(Electronic)%201478-3223%20(Linking)&rft.issn=1478-3231%20(Electronic)%201478-3223%20(Linking)&rft.au=BOYD,%20A.&MOH,%20Desmorys%20Raoul&MAYLIN,%20S.&ABDOU%20CHEKARAOU,%20M.&MAHJOUB,%20N.&rft.genre=article


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