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Increased levels of soluble Receptor for Advanced Glycation End-products (RAGE) are associated with a higher risk of mortality in frail older adults

dc.rights.licenseopenen_US
dc.contributor.authorBUTCHER, L.
dc.contributor.authorCARNICERO, J. A.
dc.contributor.authorGOMEZ CABRERO, D.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPERES, Karine
dc.contributor.authorGARCIA-GARCIA, F. J.
dc.contributor.authorRODRIGUEZ-MANAS, L.
dc.contributor.authorERUSALIMSKY, J. D.
dc.contributor.authorCONSORTIUM, Frailomic
dc.date.accessioned2020-05-25T14:49:57Z
dc.date.available2020-05-25T14:49:57Z
dc.date.issued2019
dc.identifier.issn1468-2834 (Electronic) 0002-0729 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7682
dc.description.abstractEnOBJECTIVE: to evaluate the relationship between serum levels of the soluble Receptor for Advanced Glycation End-products (sRAGE) and mortality in frail and non-frail older adults. METHODS: we studied 691 subjects (141 frail and 550 non-frail) with a median age of 75 years from two population-based cohorts, the Toledo Study of Healthy Aging and the AMI study, who were enrolled to the FRAILOMIC initiative. Multivariate Cox proportional hazards regression and Kaplan-Meier survival analysis were used to assess the relationship between baseline sRAGE and mortality. RESULTS: during 6 years of follow-up 101 participants died (50 frail and 51 non-frail). Frail individuals who died had significantly higher sRAGE levels than those who survived (median [IQR]: 1563 [1015-2248] vs 1184 [870-1657] pg/ml, P = 0.006), whilst no differences were observed in the non-frail group (1262 [1056-1554] vs 1186 [919-1551] pg/ml, P = 0.19). Among frail individuals higher sRAGE levels were associated with an increased risk of death after adjustment for relevant covariates (HR = 2.72 per unit increment in ln-sRAGE, 95%CI 1.48-4.99, P = 0.001). In contrast, in non-frail individuals sRAGE showed no association with mortality. Survival curves demonstrated that among frail individuals the incidence of death was significantly higher in the top sRAGE quartile compared to the three lower quartiles (P = 0.002). Area under the ROC curve analysis demonstrated that for frail individuals, inclusion of sRAGE in the hazard model increased its predictive accuracy by ~3%. CONCLUSIONS: sRAGE is an independent predictor of mortality among frail individuals. Determination of sRAGE in frail subjects could be useful for prognostic assessment and treatment stratification.
dc.language.isoENen_US
dc.subject.enSEPIA
dc.title.enIncreased levels of soluble Receptor for Advanced Glycation End-products (RAGE) are associated with a higher risk of mortality in frail older adults
dc.title.alternativeAge Ageingen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ageing/afz073en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31211360en_US
bordeaux.journalAge and Ageingen_US
bordeaux.page696-702en_US
bordeaux.volume48en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03209898
hal.version1
hal.date.transferred2021-04-27T13:16:38Z
hal.exporttrue
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