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Secondary prevention of acute coronary events with antiplatelet agents (SPACE-AA): One-year real-world effectiveness and safety cohort study in the French nationwide claims database

dc.rights.licenseopenen_US
dc.contributor.authorBLIN, Patrick
dc.contributor.authorDUREAU-POURNIN, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBENICHOU, Jacques
dc.contributor.authorBONELLO, L.
dc.contributor.authorDALLONGEVILLE, J.
dc.contributor.authorDANCHIN, N.
dc.contributor.authorFALISSARD, B.
dc.contributor.authorTHOMAS-DELECOURT, F.
dc.contributor.authorJOVE, J.
dc.contributor.authorLASSALLE, Regis
dc.contributor.authorDROZ, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOORE, Nicholas
dc.date.accessioned2020-05-19T08:26:57Z
dc.date.available2020-05-19T08:26:57Z
dc.date.issued2019
dc.identifier.issn1879-1484 (Electronic) 0021-9150 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7634
dc.description.abstractEnBACKGROUND AND AIMS: We aimed to compare the effectiveness of ticagrelor vs. clopidogrel or prasugrel on recurrence of acute coronary syndromes (ACS) in real-life conditions, as requested by regulatory authorities at the time of marketing. METHODS: We performed a cohort study in SNDS, the French national healthcare database. All patients with a hospital admission for ACS in 2013 were followed one year. Patients on ticagrelor, clopidogrel or prasugrel were matched 1:1 using age, gender, index ACS type, and high-dimensional propensity scores (hdPS). Outcomes were ACS, stroke, all-cause death, and major bleeding, compared within matched groups using Cox proportional hazards models analysis during treatment. RESULTS: 54,048 ACS were hospitalized in 2013. At discharge, 19,796 were dispensed clopidogrel, 8242 prasugrel, and 13,916 ticagrelor. Per group, 9224 ticagrelor vs. clopidogrel, 6752 ticagrelor vs. prasugrel, and 4676 prasugrel vs. clopidogrel patients were matched. Compared to clopidogrel, ticagrelor was associated with a lower hazard ratio of death 0.73 [0.59-0.90] and composite criterion (0.88, 95% CI [0.79-0.99] but not ACS 0.92 [0.80-1.06], stroke (0.96 [017-5.53]) or major bleeding (1.02 [0.82-1.26]). Prasugrel was not different from ticagrelor or clopidogrel for any outcome, in matched patients. CONCLUSIONS: Ticagrelor in real-life conditions in matched populations was associated with a lower risk of all-cause death than clopidogrel, and a lower risk of composite outcome, as in the main pivotal clinical trial. Ticagrelor and prasugrel were not different, nor were prasugrel and clopidogrel.
dc.language.isoENen_US
dc.subject.enPharmacoEpi-Drugs
dc.title.enSecondary prevention of acute coronary events with antiplatelet agents (SPACE-AA): One-year real-world effectiveness and safety cohort study in the French nationwide claims database
dc.title.alternativeAtherosclerosisen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.atherosclerosis.2018.11.037en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30658197en_US
bordeaux.journalAtherosclerosisen_US
bordeaux.page98-106en_US
bordeaux.volume281en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Atherosclerosis&rft.date=2019&rft.volume=281&rft.spage=98-106&rft.epage=98-106&rft.eissn=1879-1484%20(Electronic)%200021-9150%20(Linking)&rft.issn=1879-1484%20(Electronic)%200021-9150%20(Linking)&rft.au=BLIN,%20Patrick&DUREAU-POURNIN,%20C.&BENICHOU,%20Jacques&BONELLO,%20L.&DALLONGEVILLE,%20J.&rft.genre=article


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