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Determinants of Statural Growth in European Children With Chronic Kidney Disease: Findings From the Cardiovascular Comorbidity in Children With Chronic Kidney Disease (4C) Study

dc.rights.licenseopenen_US
dc.contributor.authorBEHNISCH, R.
dc.contributor.authorKIRCHNER, M.
dc.contributor.authorANARAT, A.
dc.contributor.authorBACCHETTA, J.
dc.contributor.authorSHROFF, R.
dc.contributor.authorBILGINER, Y.
dc.contributor.authorMIR, S.
dc.contributor.authorCALISKAN, S.
dc.contributor.authorPARIPOVIC, D.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
dc.contributor.authorMENCARELLI, F.
dc.contributor.authorBUSCHER, R.
dc.contributor.authorARBEITER, K.
dc.contributor.authorSOYLEMEZOGLU, O.
dc.contributor.authorZALOSZYC, A.
dc.contributor.authorZUROWSKA, A.
dc.contributor.authorMELK, A.
dc.contributor.authorQUERFELD, U.
dc.contributor.authorSCHAEFER, F.
dc.date.accessioned2020-05-13T13:39:42Z
dc.date.available2020-05-13T13:39:42Z
dc.date.issued2019
dc.identifier.issn2296-2360 (Print) 2296-2360en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7563
dc.description.abstractEnFailure of statural growth is one of the major long-term sequelae of chronic kidney disease (CKD) in children. In recent years effective therapeutic strategies have become available that lead to evidence based practice recommendations. To assess the current growth performance of European children and adolescents with CKD, we analyzed a cohort of 594 patients from 12 European countries who were followed prospectively for up to 6 years in the 4C Study. While all patients were on conservative treatment with a mean estimated glomerular filtration rate of 28 ml/min/1.73 m(2) at study entry, 130 children commenced dialysis during the observation period. At time of enrolment the mean height standard deviation score (SDS) was -1.57; 36% of patients had a height below the third percentile. The prevalence of growth failure varied between countries from 7 to 44% Whereas patients on conservative treatment showed stable growth, height SDS gradually declined on those on dialysis. Parental height, pubertal status and treatment with recombinant growth hormone (GH) were positively, and the diagnosis of syndromic disease and CKD stage were negatively associated with height SDS during the observation period. Unexpectedly, higher body mass index (BMI) SDS was associated with lower height SDS both at enrolment and during follow up. Renal anemia, metabolic acidosis, and hyperparathyroidism were mostly mild and not predictive of growth rates by multivariable analysis. GH therapy was applied in only 15% of growth retarded patients with large variation between countries. When adjusting for all significant covariates listed above, the country of residence remained a highly significant predictor of overall growth performance. In conclusion, growth failure remains common in European children with CKD, despite improved general management of CKD complications. The widespread underutilization of GH, an approved efficacious therapy for CKD-associated growth failure, deserves further exploration.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/us/
dc.subject.enLEHA
dc.title.enDeterminants of Statural Growth in European Children With Chronic Kidney Disease: Findings From the Cardiovascular Comorbidity in Children With Chronic Kidney Disease (4C) Study
dc.title.alternativeFront Pediatren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3389/fped.2019.00278en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31334210en_US
bordeaux.journalFrontiers in Pediatricsen_US
bordeaux.page278en_US
bordeaux.volume7en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03209481
hal.version2
hal.date.transferred2021-04-28T01:50:54Z
hal.exporttrue
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