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Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion

dc.rights.licenseopenen_US
dc.contributor.authorBANCONE, G.
dc.contributor.authorMENARD, D.
dc.contributor.authorKHIM, N.
dc.contributor.authorKIM, S.
dc.contributor.authorCANIER, L.
dc.contributor.authorNGUONG, C.
dc.contributor.authorPHOMMASONE, K.
dc.contributor.authorMAYXAY, M.
dc.contributor.authorDITTRICH, S.
dc.contributor.authorVONGSOUVATH, M.
dc.contributor.authorFIEVET, N.
dc.contributor.authorLE HESRAN, J. Y.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBRIAND, Valerie
dc.contributor.authorKEOMANY, S.
dc.contributor.authorNEWTON, P. N.
dc.contributor.authorGORSAWUN, G.
dc.contributor.authorTARDY, K.
dc.contributor.authorCHU, C. S.
dc.contributor.authorRATTANAPALROJ, O.
dc.contributor.authorDONG, L. T.
dc.contributor.authorQUANG, H. H.
dc.contributor.authorTAM-UYEN, N.
dc.contributor.authorTHUY-NHIEN, N.
dc.contributor.authorHIEN, T. T.
dc.contributor.authorKALNOKY, M.
dc.contributor.authorNOSTEN, F.
dc.date.accessioned2020-05-11T08:52:09Z
dc.date.available2020-05-11T08:52:09Z
dc.date.issued2019
dc.identifier.issn1475-2875en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7509
dc.description.abstractEnBACKGROUND: Plasmodium vivax malaria elimination can only be achieved by the deployment of 8-aminoquinolines (primaquine and tafenoquine) in combination with ACT to kill both blood and liver-stage parasites. However, primaquine and the other 8-aminoquinolines cause dose-dependent haemolysis in subjects with G6PD deficiency, an X-linked disorder of red blood cells that is very common in populations living in tropical and subtropical areas. In order to inform safer use of 8-aminoquinolines in the Greater Mekong Subregion, a multi-centre study was carried out to assess the prevalence of G6PD deficiency and to identify the main G6PD variants in samples collected in Cambodia, Lao PDR, Myanmar, Thailand and Vietnam. METHODS: Blood samples were collected in the five countries during National Malaria Surveys or during Population Surveys. During Population Surveys samples were characterized for G6PD phenotype using the Fluorescent Spot Test. Samples were then genotyped for a panel of G6PD mutations. RESULTS: G6PD deficiency was found to be common in the region with an overall mean prevalence of deficient or mutated hemizygous males of 14.0%, ranging from a mean 7.3% in Thailand, 8.1% in Lao PDR, 8.9% in Vietnam, 15.8% in Myanmar and 18.8% in Cambodia. Mahidol and Viangchan mutations were the most common and widespread variants found among the nine investigated. CONCLUSIONS: Owing to the high prevalence of G6PD deficiency in the Greater Mekong Subregion, strategies for vivax malaria elimination should include point-of-care G6PD testing (both qualitative and quantitative) to allow safe and wide treatment with 8-aminoquinolines.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/us/
dc.subject.enIDLIC
dc.title.enMolecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion
dc.title.alternativeMalar Jen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s12936-019-2652-yen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30674319en_US
bordeaux.journalMalaria journalen_US
bordeaux.page20en_US
bordeaux.volume18en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Malaria%20journal&rft.date=2019&rft.volume=18&rft.issue=1&rft.spage=20&rft.epage=20&rft.eissn=1475-2875&rft.issn=1475-2875&rft.au=BANCONE,%20G.&MENARD,%20D.&KHIM,%20N.&KIM,%20S.&CANIER,%20L.&rft.genre=article


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