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Low levels of urinary epidermal growth factor predict chronic kidney disease progression in children

dc.rights.licenseopenen_US
dc.contributor.authorAZUKAITIS, K.
dc.contributor.authorJU, W.
dc.contributor.authorKIRCHNER, M.
dc.contributor.authorNAIR, V.
dc.contributor.authorSMITH, M.
dc.contributor.authorFANG, Z.
dc.contributor.authorTHURN-VALSASSINA, D.
dc.contributor.authorBAYAZIT, A.
dc.contributor.authorNIEMIRSKA, A.
dc.contributor.authorCANPOLAT, N.
dc.contributor.authorBULUT, I. K.
dc.contributor.authorYALCINKAYA, F.
dc.contributor.authorPARIPOVIC, D.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
dc.contributor.authorCAKAR, N.
dc.contributor.authorALPAY, H.
dc.contributor.authorLUGANI, F.
dc.contributor.authorMENCARELLI, F.
dc.contributor.authorCIVILIBAL, M.
dc.contributor.authorERDOGAN, H.
dc.contributor.authorGELLERMANN, J.
dc.contributor.authorVIDAL, E.
dc.contributor.authorTABEL, Y.
dc.contributor.authorGIMPEL, C.
dc.contributor.authorERTAN, P.
dc.contributor.authorYAVASCAN, O.
dc.contributor.authorMELK, A.
dc.contributor.authorQUERFELD, U.
dc.contributor.authorWUHL, E.
dc.contributor.authorKRETZLER, M.
dc.contributor.authorSCHAEFER, F.
dc.contributor.authorSTUDY, C.
dc.contributor.authorGROUP, Escape Trial
dc.date.accessioned2020-05-07T09:35:10Z
dc.date.available2020-05-07T09:35:10Z
dc.date.issued2019
dc.identifier.issn1523-1755 (Electronic) 0085-2538 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7504
dc.description.abstractEnUrinary epidermal growth factor (uEGF) has recently been identified as a promising biomarker of chronic kidney disease (CKD) progression in adults with glomerular disease. Low levels of uEGF predict CKD progression and appear to reflect the extent of tubulointerstitial damage. We investigated the relevance of uEGF in pediatric CKD. We performed a post hoc analysis of the Cardiovascular Comorbidity in Children with CKD (4C) study, which prospectively follows children aged 6-17 years with baseline estimated glomerular filtration rate (eGFR) of 10-60 ml/min/1.73 m(2). uEGF levels were measured in archived urine collected within 6 months of enrollment. Congenital abnormalities of the kidney and urinary tract were the most common cause of CKD, with glomerular diseases accounting for <10% of cases. Median eGFR at baseline was 28 ml/min/1.73 m(2), and 288 of 623 participants (46.3%) reached the composite endpoint of CKD progression (50% eGFR loss, eGFR < 10 ml/min/1.73 m(2), or initiation of renal replacement therapy). In a Cox proportional hazards model, higher uEGF/Cr was associated with a decreased risk of CKD progression (HR 0.76; 95% CI 0.69-0.84) independent of age, sex, baseline eGFR, primary kidney disease, proteinuria, and systolic blood pressure. The addition of uEGF/Cr to a model containing these variables resulted in a significant improvement in C-statistics, indicating better prediction of the 1-, 2- and 3-year risk of CKD progression. External validation in a prospective cohort of 222 children with CKD demonstrated comparable results. Thus, uEGF may be a useful biomarker to predict CKD progression in children with CKD.
dc.language.isoENen_US
dc.subject.enLEHA
dc.title.enLow levels of urinary epidermal growth factor predict chronic kidney disease progression in children
dc.title.alternativeKidney Inten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.kint.2019.01.035en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31005273en_US
bordeaux.journalKidney Internationalen_US
bordeaux.page214-221en_US
bordeaux.volume96en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03209965
hal.version1
hal.date.transferred2021-04-27T13:46:51Z
hal.exporttrue
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