Subfoveal Choroidal Thickness, Cardiovascular History, and Risk Factors in the Elderly: The Montrachet Study
| dc.rights.license | open | en_US |
| dc.contributor.author | ARNOULD, L. | |
| dc.contributor.author | SEYDOU, A. | |
| dc.contributor.author | GABRIELLE, P. H. | |
| dc.contributor.author | GUENANCIA, C. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | TZOURIO, Christophe
IDREF: 69829209 | |
| dc.contributor.author | BOURREDJEM, A. | |
| dc.contributor.author | EL ALAMI, Y. | |
| dc.contributor.author | DAIEN, V. | |
| dc.contributor.author | BINQUET, C. | |
| dc.contributor.author | BRON, A. M. | |
| dc.contributor.author | CREUZOT-GARCHER, C. | |
| dc.date.accessioned | 2020-05-07T08:56:30Z | |
| dc.date.available | 2020-05-07T08:56:30Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 0146-0404 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/7499 | |
| dc.description.abstractEn | Purpose: To measure subfoveal choroidal thickness (SFCT) in the elderly and to determine the associations among SFCT, cardiovascular history, and the 10-year risk of fatal cardiovascular disease (CVD). Methods: We conducted a population-based study, the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular, and HEarT disease) study, in subjects older than 75 years. SFCT was measured with spectral-domain optical coherence tomography (SD-OCT) with enhanced-depth mode imaging. Participants underwent a comprehensive eye examination. The history of CVD, CVD risk factors, and a score-based estimation of their 10-year risk of cardiovascular mortality (Heart Score) were collected. Results: Overall, 764 participants were retained for analysis. The mean SFCT was 206.4 +/- 83.0 mum. The mean age was 81.9 +/- 3.6 years. After a multivariable analysis, older age (beta = -32.56 mum, P < 0.001) and longer axial length (beta = -20.71 mum, P < 0.001) were independently associated with thinner SFCT. SFCT was not significantly associated with sex, cardiovascular history, classical CVD risk factors, or prognostic risk score. Conclusions: This study confirms that longer axial length and older age are associated with thinner SFCT. However, SFCT does not appear to be a biomarker for cardiovascular history in this study. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Unported | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ | |
| dc.subject.en | HEALTHY | |
| dc.title.en | Subfoveal Choroidal Thickness, Cardiovascular History, and Risk Factors in the Elderly: The Montrachet Study | |
| dc.title.alternative | Invest Ophthalmol Vis Sci | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1167/iovs.18-26488 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 31158275 | en_US |
| bordeaux.journal | Investigative ophthalmology & visual science | en_US |
| bordeaux.page | 2431-2437 | en_US |
| bordeaux.volume | 60 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 7 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
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