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Subfoveal Choroidal Thickness, Cardiovascular History, and Risk Factors in the Elderly: The Montrachet Study

dc.rights.licenseopenen_US
dc.contributor.authorARNOULD, L.
dc.contributor.authorSEYDOU, A.
dc.contributor.authorGABRIELLE, P. H.
dc.contributor.authorGUENANCIA, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
dc.contributor.authorBOURREDJEM, A.
dc.contributor.authorEL ALAMI, Y.
dc.contributor.authorDAIEN, V.
dc.contributor.authorBINQUET, C.
dc.contributor.authorBRON, A. M.
dc.contributor.authorCREUZOT-GARCHER, C.
dc.date.accessioned2020-05-07T08:56:30Z
dc.date.available2020-05-07T08:56:30Z
dc.date.issued2019
dc.identifier.issn0146-0404en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7499
dc.description.abstractEnPurpose: To measure subfoveal choroidal thickness (SFCT) in the elderly and to determine the associations among SFCT, cardiovascular history, and the 10-year risk of fatal cardiovascular disease (CVD). Methods: We conducted a population-based study, the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular, and HEarT disease) study, in subjects older than 75 years. SFCT was measured with spectral-domain optical coherence tomography (SD-OCT) with enhanced-depth mode imaging. Participants underwent a comprehensive eye examination. The history of CVD, CVD risk factors, and a score-based estimation of their 10-year risk of cardiovascular mortality (Heart Score) were collected. Results: Overall, 764 participants were retained for analysis. The mean SFCT was 206.4 +/- 83.0 mum. The mean age was 81.9 +/- 3.6 years. After a multivariable analysis, older age (beta = -32.56 mum, P < 0.001) and longer axial length (beta = -20.71 mum, P < 0.001) were independently associated with thinner SFCT. SFCT was not significantly associated with sex, cardiovascular history, classical CVD risk factors, or prognostic risk score. Conclusions: This study confirms that longer axial length and older age are associated with thinner SFCT. However, SFCT does not appear to be a biomarker for cardiovascular history in this study.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.enHEALTHY
dc.title.enSubfoveal Choroidal Thickness, Cardiovascular History, and Risk Factors in the Elderly: The Montrachet Study
dc.title.alternativeInvest Ophthalmol Vis Scien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1167/iovs.18-26488en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31158275en_US
bordeaux.journalInvestigative ophthalmology & visual scienceen_US
bordeaux.page2431-2437en_US
bordeaux.volume60en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Investigative%20ophthalmology%20&%20visual%20science&amp;rft.date=2019&amp;rft.volume=60&amp;rft.issue=7&amp;rft.spage=2431-2437&amp;rft.epage=2431-2437&amp;rft.eissn=0146-0404&amp;rft.issn=0146-0404&amp;rft.au=ARNOULD,%20L.&amp;SEYDOU,%20A.&amp;GABRIELLE,%20P.%20H.&amp;GUENANCIA,%20C.&amp;TZOURIO,%20Christophe&amp;rft.genre=article


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