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Cystic fibrosis and noninvasive liver fibrosis assessment methods in children

dc.rights.licenseopenen_US
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorENAUD, Raphael
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFRISON, Eric
dc.contributor.authorMISSONNIER, Sophie
dc.contributor.authorFISCHER, Aude
dc.contributor.authorDE LEDINGHEN, Victor
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPEREZ, Paul
dc.contributor.authorBUI, Stephanie
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFAYON, Michael
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorCHATEIL, Jean-Francois
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLAMIREAU, Thierry
dc.date.accessioned2021-05-11T12:11:02Z
dc.date.available2021-05-11T12:11:02Z
dc.date.issued2021-03-17
dc.identifier.issn1530-0447 (Electronic) 0031-3998 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/72140
dc.description.abstractEnBACKGROUND: Noninvasive assessments of liver fibrosis are currently used to evaluate cystic fibrosis (CF)-related liver disease. However, there is scarce data regarding their repeatability and reproducibility, especially in children with CF. The present study aimed to evaluate the repeatability and reproducibility of transient elastography (TE) (FibroScan®) and point shear-wave elastography using virtual touch quantification (pSWE VTQ) in children with CF. METHODS: TE and pSWE VTQ were performed in 56 children with CF by two different operators. Analysis of repeatability and reproducibility was available in 33 patients for TE and 46 patients for pSWE VTQ. Intra- and interobserver agreement were assessed using the intraclass correlation coefficient (ICC) and their 95% confidence interval (CI), and Bland and Altman graphs. RESULTS: For TE, ICC was 0.91 (0.83-0.95) for intraobserver agreement and 0.92 (95% CI: 0.86-0.96) for interobserver agreement. For pSWE VTQ, ICC was 0.83 (0.72-0.90) for intraobserver agreement and 0.67 (0.48-0.80) for interobserver agreement. CONCLUSIONS: Both technics can be proposed in the follow-up of patients, according to their availability in CF centers. IMPACT: This study shows that TE and pSWE VTQ are reliable methods to evaluate liver fibrosis in children with CF. This study shows for the first time that TE and pSWE VTQ are both repeatable and reproducible in children with CF. These data indicate that both TE and pSWE VTQ can be proposed for the follow-up of patients with CF, according to their availability in each CF center.
dc.language.isoENen_US
dc.title.enCystic fibrosis and noninvasive liver fibrosis assessment methods in children
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41390-021-01427-4en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33731812en_US
bordeaux.journalPediatric Researchen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamUSMRen_US
bordeaux.teamCIC1401en_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03224151
hal.version1
hal.date.transferred2021-05-11T12:11:06Z
hal.exporttrue
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