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n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies

dc.rights.licenseopenen_US
dc.contributor.authorQIAN, Frank
dc.contributor.authorARDISSON KORAT, Andres V.
dc.contributor.authorIMAMURA, Fumiaki
dc.contributor.authorMARKLUND, Matti
dc.contributor.authorTINTLE, Nathan
dc.contributor.authorVIRTANEN, Jyrki K.
dc.contributor.authorZHOU, Xia
dc.contributor.authorBASSETT, Julie K.
dc.contributor.authorLAI, Heidi
dc.contributor.authorHIRAKAWA, Yoichiro
dc.contributor.authorCHIEN, Kuo-Liong
dc.contributor.authorWOOD, Alexis C.
dc.contributor.authorLANKINEN, Maria
dc.contributor.authorMURPHY, Rachel A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.contributor.authorPERTIWI, Kamalita
dc.contributor.authorDE MELLO, Vanessa D.
dc.contributor.authorGUAN, Weihua
dc.contributor.authorFOROUHI, Nita G.
dc.contributor.authorWAREHAM, Nick
dc.contributor.authorHU, InterAct Consortium Frank B
dc.contributor.authorRISERUS, Ulf
dc.contributor.authorLIND, Lars
dc.contributor.authorHARRIS, William S.
dc.contributor.authorSHADYAB, Aladdin H.
dc.contributor.authorROBINSON, Jennifer G.
dc.contributor.authorSTEFFEN, Lyn M.
dc.contributor.authorHODGE, Allison
dc.contributor.authorGILES, Graham G.
dc.contributor.authorNINOMIYA, Toshiharu
dc.contributor.authorUUSITUPA, Matti
dc.contributor.authorTUOMILEHTO, Jaakko
dc.contributor.authorLINDSTROM, Jaana
dc.contributor.authorLAAKSO, Markku
dc.contributor.authorSISCOVICK, David S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorGELEIJNSE, Johanna M.
dc.contributor.authorWU, Jason H. Y.
dc.contributor.authorFRETTS, Amanda
dc.contributor.authorLEMAITRE, Rozenn N.
dc.contributor.authorMICHA, Renata
dc.contributor.authorMOZAFFARIAN, Dariush
dc.contributor.authorSUN, Qi
dc.contributor.authorFATTY, Acids
dc.contributor.authorOUTCOMES RESEARCH, Consortium
dc.date.accessioned2021-05-07T14:23:30Z
dc.date.available2021-05-07T14:23:30Z
dc.date.issued2021-03-03
dc.identifier.issn1935-5548 (Electronic) 0149-5992 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/27215
dc.description.abstractEnOBJECTIVE: Prospective associations between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk are not consistent in individual studies. We aimed to summarize the prospective associations of biomarkers of α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis. RESEARCH DESIGN AND METHODS: For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries. We included 65,147 participants who had blood measurements of ALA, EPA, DPA, or DHA and were free of diabetes at baseline. De novo harmonized analyses were performed in each cohort following a prespecified protocol, and cohort-specific associations were pooled using inverse variance-weighted meta-analysis. RESULTS: A total of 16,693 incident T2D cases were identified during follow-up (median follow-up ranging from 2.5 to 21.2 years). In pooled multivariable analysis, per interquintile range (difference between the 90th and 10th percentiles for each fatty acid), EPA, DPA, DHA, and their sum were associated with lower T2D incidence, with hazard ratios (HRs) and 95% CIs of 0.92 (0.87, 0.96), 0.79 (0.73, 0.85), 0.82 (0.76, 0.89), and 0.81 (0.75, 0.88), respectively (all P < 0.001). ALA was not associated with T2D (HR 0.97 [95% CI 0.92, 1.02]) per interquintile range. Associations were robust across prespecified subgroups as well as in sensitivity analyses. CONCLUSIONS: Higher circulating biomarkers of seafood-derived n-3 fatty acids, including EPA, DPA, DHA, and their sum, were associated with lower risk of T2D in a global consortium of prospective studies. The biomarker of plant-derived ALA was not significantly associated with T2D risk.
dc.language.isoENen_US
dc.title.enn-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies
dc.title.alternativeDiabetes Careen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.2337/dc20-2426en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33658295en_US
bordeaux.journalDiabetes Careen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPH
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03221035
hal.version1
hal.date.transferred2021-05-08T01:51:58Z
hal.exporttrue
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