Mostrar el registro sencillo del ítem

A Treatment-Decision Score for HIV-Infected Children With Suspected Tuberculosis

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMARCY, Olivier
dc.contributor.authorBORAND, Laurence
dc.contributor.authorUNG, Vibol
dc.contributor.authorMSELLATI, Philippe
dc.contributor.authorTEJIOKEM, Mathurin
dc.contributor.authorHUU, Khanh Truong
dc.contributor.authorDO CHAU, Viet
dc.contributor.authorNGOC TRAN, Duong
dc.contributor.authorATEBA-NDONGO, Francis
dc.contributor.authorTETANG-NDIANG, Suzie
dc.contributor.authorNACRO, Boubacar
dc.contributor.authorSANOGO, Bintou
dc.contributor.authorNEOU, Leakhena
dc.contributor.authorGOYET, Sophie
dc.contributor.authorDIM, Bunnet
dc.contributor.authorPEAN, Polidy
dc.contributor.authorQUILLET, Catherine
dc.contributor.authorFOURNIER, Isabelle
dc.contributor.authorBERTELOOT, Laureline
dc.contributor.authorCARCELAIN, Guislaine
dc.contributor.authorGODREUIL, Sylvain
dc.contributor.authorBLANCHE, Stéphane
dc.contributor.authorDELACOURT, Christophe
dc.date.accessioned2021-04-30T09:05:34Z
dc.date.available2021-04-30T09:05:34Z
dc.date.issued2019-09-02
dc.identifier.issn0031-4005en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/27136
dc.description.abstractEnBACKGROUND: Diagnosis of tuberculosis should be improved in children infected with HIV to reduce mortality. We developed prediction scores to guide antituberculosis treatment decision in HIV-infected children with suspected tuberculosis.METHODS: HIV-infected children with suspected tuberculosis enrolled in Burkina Faso, Cambodia, Cameroon, and Vietnam (ANRS 12229 PAANTHER 01 Study), underwent clinical assessment, chest radiography, Quantiferon Gold In-Tube (QFT), abdominal ultrasonography, and sample collection for microbiology, including Xpert MTB/RIF (Xpert). We developed 4 tuberculosis diagnostic models using logistic regression: (1) all predictors included, (2) QFT excluded, (3) ultrasonography excluded, and (4) QFT and ultrasonography excluded. We internally validated the models using resampling. We built a score on the basis of the model with the best area under the receiver operating characteristic curve and parsimony.RESULTS: A total of 438 children were enrolled in the study; 251 (57.3%) had tuberculosis, including 55 (12.6%) with culture- or Xpert-confirmed tuberculosis. The final 4 models included Xpert, fever lasting >2 weeks, unremitting cough, hemoptysis and weight loss in the past 4 weeks, contact with a patient with smear-positive tuberculosis, tachycardia, miliary tuberculosis, alveolar opacities, and lymph nodes on the chest radiograph, together with abdominal lymph nodes on the ultrasound and QFT results. The areas under the receiver operating characteristic curves were 0.866, 0.861, 0.850, and 0.846, for models 1, 2, 3, and 4, respectively. The score developed on model 2 had a sensitivity of 88.6% and a specificity of 61.2% for a tuberculosis diagnosis.CONCLUSIONS: Our score had a good diagnostic performance. Used in an algorithm, it should enable prompt treatment decision in children with suspected tuberculosis and a high mortality risk, thus contributing to significant public health benefits.
dc.language.isoENen_US
dc.subject.enInfectious Disease
dc.subject.enHIV/AIDS
dc.title.enA Treatment-Decision Score for HIV-Infected Children With Suspected Tuberculosis
dc.typeArticle de revueen_US
dc.identifier.doi10.1542/peds.2018-2065en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieusesen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31455612en_US
bordeaux.journalPediatricsen_US
bordeaux.pagee20182065en_US
bordeaux.volume144en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamIDLICen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-02332878
hal.version1
hal.exportfalse
workflow.import.sourcehal
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Pediatrics&rft.date=2019-09-02&rft.volume=144&rft.issue=3&rft.spage=e20182065&rft.epage=e20182065&rft.eissn=0031-4005&rft.issn=0031-4005&rft.au=MARCY,%20Olivier&BORAND,%20Laurence&UNG,%20Vibol&MSELLATI,%20Philippe&TEJIOKEM,%20Mathurin&rft.genre=article


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem