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Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS)

dc.rights.licenseopenen_US
dc.contributor.authorTRIEBNER, Kai
dc.contributor.authorBIFULCO, Ersilia
dc.contributor.authorBARRERA-GOMEZ, Jose
dc.contributor.authorBASAGANA, Xavier
dc.contributor.authorBENEDIKTSDOTTIR, Bryndis
dc.contributor.authorFORSBERG, Bertil
dc.contributor.authorFRANKLIN, Karl A.
dc.contributor.authorGARCIA-LARSEN, Vanessa
dc.contributor.authorLEYNAERT, Benedicte
dc.contributor.authorLINDBERG, Eva
dc.contributor.authorMARTINEZ-MORATALLA, Jesus
dc.contributor.authorMUNIOZGUREN-AGIRRE, Nerea
dc.contributor.authorPIN, Isabelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAHERISON-SEMJEN, Chantal
dc.contributor.authorPEREIRA-VEGA, Antonio
dc.contributor.authorSCHLUNSSEN, Vivi
dc.contributor.authorVALENTIN, Antonia
dc.contributor.authorHUSTAD, Steinar
dc.contributor.authorREAL, Francisco Gomez
dc.contributor.authorDADVAND, Payam
dc.date.accessioned2021-04-21T11:29:19Z
dc.date.available2021-04-21T11:29:19Z
dc.date.issued2021-03
dc.identifier.issn1873-4111 (Electronic) 0378-5122 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/27006
dc.description.abstractEnBACKGROUND: Solar ultraviolet radiation (UVR) affects the body through pathways that exhibit positive as well as negative health effects such as immunoregulation and vitamin D production. Different vitamin D metabolites are associated with higher or lower concentrations of estrogens and may thus alter the female sex hormone balance. OBJECTIVE: To study whether exposure to UVR, as a modifiable lifestyle factor, is associated with levels of sex hormones (17β-estradiol, estrone, estrone 3-sulfate, testosterone, dehydroepiandrosterone sulfate), gonadotropins (follicle stimulating hormone, luteinizing hormone) as well as sex hormone binding globulin in postmenopausal women, and thus investigate whether managing UVR exposure can influence the hormone balance, with potential benefits for the biological aging process. METHODS: The study included 580 postmenopausal women from six European countries, participating in the European Community Respiratory Health Survey (2010-2014). Average UVR exposure during the month before blood sampling was estimated based on personal sun behavior and ambient levels. Hormone concentrations were measured in serum using state-of-the-art methods. Subsequently we applied linear mixed-effects models, including center as random intercept, hormone concentrations (one at a time) as outcome and UVR, age, skin type, body mass index, vitamin D from dietary sources, smoking, age at completed full-time education and season of blood sampling as fixed-effect predictors. RESULTS: One interquartile range increase in UVR exposure was associated with decreased levels of 17β-estradiol (-15.6 pmol/L, 95 % Confidence Interval (CI): -27.69, -3.51) and estrone (-13.36 pmol/L, 95 % CI: -26.04, -0.68) and increased levels of follicle stimulating hormone (9.34IU/L, 95 % CI: 2.91, 15.77) and luteinizing hormone (13.86 IU/daL, 95 % CI: 2.48, 25.25). CONCLUSIONS: Exposure to UVR is associated with decreased estrogens and increased gonadotropins in postmenopausal women, a status associated with osteoporosis, lung function decline and other adverse health effects. This study indicates that managing UVR exposure has potential to influence the hormone balance and counteract adverse health conditions after menopause.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enMenopause
dc.subject.enEstrogens
dc.subject.enSunlight
dc.subject.enReproductive aging
dc.subject.enVitamin D
dc.title.enUltraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS)
dc.title.alternativeMaturitasen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.maturitas.2020.12.011en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33541562en_US
bordeaux.journalMaturitasen_US
bordeaux.page49-55en_US
bordeaux.volume145en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03204199
hal.version1
hal.date.transferred2021-04-21T11:29:24Z
hal.exporttrue
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