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Does Homeostatic Sleep Pressure Buildup Explain Objective Excessive Daytime Sleepiness in Adults With ADHD? An Exploratory Study
| dc.rights.license | open | en_US |
| hal.structure.identifier | Sommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY] | |
| dc.contributor.author | BIOULAC, Stephanie
ORCID: 0000-0003-2618-4234 IDREF: 059280824 | |
| dc.contributor.author | SAGASPE, Patricia | |
| dc.contributor.author | TRON, Eleonore | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BENARD, Antoine | |
| dc.contributor.author | BERTHOMIER, Christian | |
| dc.contributor.author | BRANDEWINDER, Marie | |
| hal.structure.identifier | Sommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY] | |
| dc.contributor.author | PHILIP, Pierre | |
| hal.structure.identifier | Sommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY] | |
| dc.contributor.author | TAILLARD, Jacques
ORCID: 0000-0001-9067-8189 IDREF: 229930786 | |
| dc.date.accessioned | 2021-04-20T11:40:11Z | |
| dc.date.available | 2021-04-20T11:40:11Z | |
| dc.date.issued | 2021-03 | |
| dc.identifier.issn | 1664-0640 (Print) 1664-0640 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26981 | |
| dc.description.abstractEn | Background: Excessive daytime sleepiness (EDS) is central in Attention deficit hyperactivity disorder (ADHD) but its causes remain unclear. The aim of this study was to explore objective EDS and homeostatic sleep pressure buildup, evaluated by power theta-alpha frequency (PTAF), in drug-free sleepy adults with ADHD and controls. Methods: Participants were placed during a 36-h period of extended wakefulness under constant routine protocol to strictly control sleep time, sleep duration, and circadian zeitgebers. Results: Eight drug-free sleepy patients with ADHD and 7 matched controls were included. The ADHD group had significantly shorter sleep latency on the Maintenance of Wakefulness Test (MWT) throughout extended wakefulness than the control group. There was no significant difference between the groups in PTAF evolution during extended wakefulness and in kinetic sleep pressure buildup, evaluated by the time constant of saturating exponential function. Limitations: The sample was small, so the findings cannot be generalized. Moreover, psychiatric comorbidities and circadian regulation should be taken into account in future studies. Conclusion: In very controlled conditions, mean sleep latency on the MWT during the whole extended wakefulness was significantly shorter in sleepy patients with ADHD than in control subjects. However, the difficulty to remain awake during soporific circumstances observed in these patients with ADHD cannot be explained by changes in the kinetic of sleep pressure buildup. Clinical Trials Registration: www.clinicaltrials.gov/, Identifier: NCT02217371. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | ADHD (attention deficit and hyperactivity disorder) | |
| dc.subject.en | Sleepiness | |
| dc.subject.en | Sleep pressure | |
| dc.subject.en | Maintenance of wakefulness test | |
| dc.subject.en | Phenotype | |
| dc.title.en | Does Homeostatic Sleep Pressure Buildup Explain Objective Excessive Daytime Sleepiness in Adults With ADHD? An Exploratory Study | |
| dc.title.alternative | Front Psychiatry | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fpsyt.2021.586528 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 33679469 | en_US |
| bordeaux.journal | Frontiers in Psychiatry | en_US |
| bordeaux.page | 586528 | en_US |
| bordeaux.volume | 12 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.team | EMOS | en_US |
| bordeaux.team | PharmacoEpi-Drugs | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Centre Hospitalier Universitaire de Bordeaux | en_US |
| hal.identifier | hal-03202991 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-04-20T11:40:15Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Psychiatry&rft.date=2021-03&rft.volume=12&rft.spage=586528&rft.epage=586528&rft.eissn=1664-0640%20(Print)%201664-0640&rft.issn=1664-0640%20(Print)%201664-0640&rft.au=BIOULAC,%20Stephanie&SAGASPE,%20Patricia&TRON,%20Eleonore&BENARD,%20Antoine&BERTHOMIER,%20Christian&rft.genre=article |
