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Visual Acuity Gain Profiles and Anatomical Prognosis Factors in Patients with Drug-Naive Diabetic Macular Edema Treated with Dexamethasone Implant: The NAVEDEX Study

dc.rights.licenseopenen_US
dc.contributor.authorPINTO, Mauricio
dc.contributor.authorMATHIS, Thibaud
dc.contributor.authorMASSIN, Pascale
dc.contributor.authorAKESBI, Jad
dc.contributor.authorLEREUIL, Theo
dc.contributor.authorVOIRIN, Nicolas
dc.contributor.authorMATONTI, Frederic
dc.contributor.authorFAJNKUCHEN, Franck
dc.contributor.authorCONRATH, John
dc.contributor.authorMILAZZO, Solange
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorKOROBELNIK, Jean-Francois
dc.contributor.authorBAILLIF, Stephanie
dc.contributor.authorDENIS, Philippe
dc.contributor.authorCREUZOT-GARCHER, Catherine
dc.contributor.authorSROUR, Mayer
dc.contributor.authorDUPAS, Benedicte
dc.contributor.authorSUDHALKAR, Aditya
dc.contributor.authorBILGIC, Alper
dc.contributor.authorTADAYONI, Ramin
dc.contributor.authorSOUIED, Eric H.
dc.contributor.authorDOT, Corinne
dc.contributor.authorKODJIKIAN, Laurent
dc.date.accessioned2021-04-06T14:23:11Z
dc.date.available2021-04-06T14:23:11Z
dc.date.issued2021-02-01
dc.identifier.issn1999-4923 (Print)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26879
dc.description.abstractEnThe purpose of this study is to evaluate the visual acuity (VA) gain profiles between patients with drug-naive diabetic macular edema (DME) treated by dexamethasone implant (DEX-implant) and assess the baseline anatomical and functional factors that could influence the response to the treatment in real-life conditions. A retrospective, multi-center observational study included 129 eyes with drug-naive DME treated by DEX-implant. The Median follow-up was 13 months. Two groups of VA gain trajectories were identified-Group A, with 71% (n = 96) of patients whose average VA gain was less than five letters and Group B, with 29% (n = 33) of patients with an average gain of 20 letters. The probability of belonging to Group B was significantly higher in patients with baseline VA \textbackslashtextless 37 letters (p = 0.001). Ellipsoid zone alterations (EZAs) or disorganization of retinal inner layers (DRILs) were associated with a lower final VA (53.0 letters versus 66.4, p = 0.002) but without a significant difference in VA gain (4.9 letters versus 6.8, p = 0.582). Despite a low baseline VA, this subgroup of patients tends to have greater visual gain, encouraging treatment with DEX-implant in such advanced-stage disease. However, some baseline anatomic parameters, such as the presence of EZAs or DRILs, negatively influenced final vision.
dc.language.isoENen_US
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.endexamethasone-implant
dc.subject.enDiabetic macular edema
dc.subject.enVisual acuity gain
dc.title.enVisual Acuity Gain Profiles and Anatomical Prognosis Factors in Patients with Drug-Naive Diabetic Macular Edema Treated with Dexamethasone Implant: The NAVEDEX Study
dc.title.alternativePharmaceuticsen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/pharmaceutics13020194en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33535719en_US
bordeaux.journalPharmaceuticsen_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERM
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03190826
hal.version1
hal.date.transferred2021-04-06T14:23:17Z
hal.audienceInternationale
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Pharmaceutics&rft.date=2021-02-01&rft.volume=13&rft.issue=2&rft.eissn=1999-4923%20(Print)&rft.issn=1999-4923%20(Print)&rft.au=PINTO,%20Mauricio&MATHIS,%20Thibaud&MASSIN,%20Pascale&AKESBI,%20Jad&LEREUIL,%20Theo&rft.genre=article


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