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Cannabis use and reduced risk of elevated fatty liver index in HIV-HCV co-infected patients: a longitudinal analysis (ANRS CO13 HEPAVIH)

dc.rights.licenseopenen_US
dc.contributor.authorBARRE, Tangui
dc.contributor.authorROJAS ROJAS, Teresa
dc.contributor.authorLACOMBE, Karine
dc.contributor.authorPROTOPOPESCU, Camelia
dc.contributor.authorPOIZOT-MARTIN, Isabelle
dc.contributor.authorNISHIMWE, Marie
dc.contributor.authorZUCMAN, David
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorESTERLE, Laure
dc.contributor.authorBILLAUD, Eric
dc.contributor.authorAUMAITRE, Hugues
dc.contributor.authorBOUCHAUD, Olivier
dc.contributor.authorREY, David
dc.contributor.authorPIROTH, Lionel
dc.contributor.authorSALMON-CERON, Dominique
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.contributor.authorSOGNI, Philippe
dc.contributor.authorCARRIERI, Maria Patrizia
dc.contributor.authorSERFATY, Lawrence
dc.contributor.authorMARCELLIN, Fabienne
dc.date.accessioned2021-03-30T13:04:29Z
dc.date.available2021-03-30T13:04:29Z
dc.date.issued2021-02-04
dc.identifier.issn1478-7210en_US
dc.identifier.urioai:crossref.org:10.1080/14787210.2021.1884545
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26832
dc.description.abstractEnBackground: Cannabis use and elevated fatty liver index (FLI≥ 60) (a biomarker of hepatic steatosis in the general population) have been identified as predictors of HCV-related and overall mortality, respectively, in HIV-HCV co-infected patients. However, the relationship between cannabis use and the risk of elevated FLI has never been explored. Methods: Using five-year follow-up data from 997 HIV-HCV co-infected patients (ANRS CO13 HEPAVIH cohort), we analyzed the relationship between cannabis use and FLI using mixed-effects multivariable logistic (outcome: elevated FLI yes/no) and linear (outcome: continuous FLI) regression models. Results: At the last follow-up visit, 27.4% of patients reported regular or daily cannabis use and 27.8% had elevated FLI. After multivariable adjustment, regular or daily cannabis use was associated with a 55% lower risk of elevated FLI (adjusted odds ratio [95% confidence interval]: 0.45 [0.22; 0.94]; p = 0.033) and lower FLI values (adjusted model coefficient: -4.24 [-6.57; -1.91], p<0.0001). Conclusions: Cannabis use is associated with a reduced risk of elevated fatty liver index in HIV-HCV co-infected patients. Further research is needed to confirm whether and how cannabinoids may inhibit the development of hepatic steatosis or other metabolic disorders in high-risk populations.
dc.language.isoENen_US
dc.sourcecrossref
dc.subject.enCannabis
dc.subject.enHepatitis C
dc.subject.enChronic
dc.subject.enHuman immunodeficiency virus
dc.subject.enFatty liver
dc.subject.enMetabolic diseases
dc.title.enCannabis use and reduced risk of elevated fatty liver index in HIV-HCV co-infected patients: a longitudinal analysis (ANRS CO13 HEPAVIH)
dc.title.alternativeExpert Rev Anti Infect Theren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1080/14787210.2021.1884545en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33538612en_US
bordeaux.journalExpert Review of Anti-infective Therapyen_US
bordeaux.page1-10en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
bordeaux.import.sourcedissemin
hal.identifierhal-03185691
hal.version1
hal.date.transferred2021-03-30T13:04:33Z
hal.exporttrue
workflow.import.sourcedissemin
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Expert%20Review%20of%20Anti-infective%20Therapy&amp;rft.date=2021-02-04&amp;rft.spage=1-10&amp;rft.epage=1-10&amp;rft.eissn=1478-7210&amp;rft.issn=1478-7210&amp;rft.au=BARRE,%20Tangui&amp;ROJAS%20ROJAS,%20Teresa&amp;LACOMBE,%20Karine&amp;PROTOPOPESCU,%20Camelia&amp;POIZOT-MARTIN,%20Isabelle&amp;rft.genre=article


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