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Severe Adverse Events during Medical and Surgical Treatment of Hip and Knee Prosthetic Joint Infections

dc.rights.licenseopenen_US
dc.contributor.authorPEREZ, S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDAUCHY, Frederic-Antoine
dc.contributor.authorSALVO, Francesco
dc.contributor.authorQUEROUE, M.
dc.contributor.authorDUROX, H.
dc.contributor.authorDELOBEL, P.
dc.contributor.authorCHAMBAULT, R.
dc.contributor.authorADE, M.
dc.contributor.authorCAZANAVE, C.
dc.contributor.authorDESCLAUX, A.
dc.contributor.authorFABRE, T.
dc.contributor.authorDUTRONC, H.
dc.date.accessioned2021-03-22T13:47:22Z
dc.date.available2021-03-22T13:47:22Z
dc.date.issued2020-10-20
dc.identifier.issn0399-077xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26770
dc.description.abstractEnINTRODUCTION: The management of prosthetic joint infection requires a complex treatment procedure and can be associated with complications. However, the occurrence of severe adverse events during this intervention has been poorly evaluated. PATIENTS AND METHODS: A 5-year multicentric retrospective study including patients from 3 hospitals in the South-Western France referral center for complex bone and joint infections (Crioac GSO) and treated for hip or knee prosthetic joint infection with 1 or 2-stage implant exchanges. The objective was to describe grade ≥ 3 adverse events, according to the CTCAE classification, occurring within 6 weeks after surgery and to identify their associated factors. RESULTS: 118 patients were identified. We observed 71 severe events in 50 patients (42.3 %; 95% confidence interval [CI95%]: 33.8-51.4%). Sixteen severe events were an evolution of the infection. The remaining 55 others (47 grade 3 and 8 grade 4) occurred in 41 patients (34.7%; CI95%: 26.8-43.7%). They were distributed as follows: 27 (49.1%) medical complications, 21 (38.2%) surgical complications and 7 (12.7%) antibiotic-related complications. The main identified risk factor was a two-stage prosthetic exchange with OR=3.6 (CI95% [1.11-11.94], p=0.032). Obesity was limit of significance with OR=3.3 (CI95 % [0.9-12.51], p=0.071). Infection with coagulase negative Staphylococcus was a protective factor with OR=0.3 (CI95% [0.12-0.99], p=0.047). CONCLUSION: Severe adverse events are frequent following prosthetic exchange for PJI (34.7%) and are related to the high frequency of comorbidities in this population and to the complex surgical procedures required. The risk factor significantly associated with these events was a two-stage exchange.
dc.language.isoENen_US
dc.title.enSevere Adverse Events during Medical and Surgical Treatment of Hip and Knee Prosthetic Joint Infections
dc.title.alternativeMed Mal Infecten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.medmal.2020.10.014en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33096203en_US
bordeaux.journalMédecine et Maladies Infectieusesen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03176552
hal.version1
hal.date.transferred2021-03-22T13:47:26Z
hal.exporttrue
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