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Severe Adverse Events during Medical and Surgical Treatment of Hip and Knee Prosthetic Joint Infections
dc.rights.license | open | en_US |
dc.contributor.author | PEREZ, S. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DAUCHY, Frederic-Antoine | |
dc.contributor.author | SALVO, Francesco
IDREF: 221043470 | |
dc.contributor.author | QUEROUE, M. | |
dc.contributor.author | DUROX, H. | |
dc.contributor.author | DELOBEL, P. | |
dc.contributor.author | CHAMBAULT, R. | |
dc.contributor.author | ADE, M. | |
dc.contributor.author | CAZANAVE, C. | |
dc.contributor.author | DESCLAUX, A. | |
dc.contributor.author | FABRE, T. | |
dc.contributor.author | DUTRONC, H. | |
dc.date.accessioned | 2021-03-22T13:47:22Z | |
dc.date.available | 2021-03-22T13:47:22Z | |
dc.date.issued | 2020-10-20 | |
dc.identifier.issn | 0399-077x | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26770 | |
dc.description.abstractEn | INTRODUCTION: The management of prosthetic joint infection requires a complex treatment procedure and can be associated with complications. However, the occurrence of severe adverse events during this intervention has been poorly evaluated. PATIENTS AND METHODS: A 5-year multicentric retrospective study including patients from 3 hospitals in the South-Western France referral center for complex bone and joint infections (Crioac GSO) and treated for hip or knee prosthetic joint infection with 1 or 2-stage implant exchanges. The objective was to describe grade ≥ 3 adverse events, according to the CTCAE classification, occurring within 6 weeks after surgery and to identify their associated factors. RESULTS: 118 patients were identified. We observed 71 severe events in 50 patients (42.3 %; 95% confidence interval [CI95%]: 33.8-51.4%). Sixteen severe events were an evolution of the infection. The remaining 55 others (47 grade 3 and 8 grade 4) occurred in 41 patients (34.7%; CI95%: 26.8-43.7%). They were distributed as follows: 27 (49.1%) medical complications, 21 (38.2%) surgical complications and 7 (12.7%) antibiotic-related complications. The main identified risk factor was a two-stage prosthetic exchange with OR=3.6 (CI95% [1.11-11.94], p=0.032). Obesity was limit of significance with OR=3.3 (CI95 % [0.9-12.51], p=0.071). Infection with coagulase negative Staphylococcus was a protective factor with OR=0.3 (CI95% [0.12-0.99], p=0.047). CONCLUSION: Severe adverse events are frequent following prosthetic exchange for PJI (34.7%) and are related to the high frequency of comorbidities in this population and to the complex surgical procedures required. The risk factor significantly associated with these events was a two-stage exchange. | |
dc.language.iso | EN | en_US |
dc.title.en | Severe Adverse Events during Medical and Surgical Treatment of Hip and Knee Prosthetic Joint Infections | |
dc.title.alternative | Med Mal Infect | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1016/j.medmal.2020.10.014 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 33096203 | en_US |
bordeaux.journal | Médecine et Maladies Infectieuses | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.team | MORPH3Eus | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-03176552 | |
hal.version | 1 | |
hal.date.transferred | 2021-03-22T13:47:26Z | |
hal.export | true | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=M%C3%A9decine%20et%20Maladies%20Infectieuses&rft.date=2020-10-20&rft.eissn=0399-077x&rft.issn=0399-077x&rft.au=PEREZ,%20S.&DAUCHY,%20Frederic-Antoine&SALVO,%20Francesco&QUEROUE,%20M.&DUROX,%20H.&rft.genre=article |
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