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Blood polyunsaturated omega‐3 fatty acids, brain atrophy, cognitive decline, and dementia risk
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | THOMAS, Aline | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BAILLET, Marion | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PROUST LIMA, Cecile
ORCID: 0000-0002-9884-955X IDREF: 114375747 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | FEART-COURET, Catherine
ORCID: 0000-0002-7959-1610 IDREF: 08195848X | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SAMIER FOUBERT, Alexandra | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HELMER, Catherine | |
| dc.contributor.author | CATHELINE, G. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SAMIERI, Cecilia | |
| dc.date.accessioned | 2021-03-22T10:30:07Z | |
| dc.date.available | 2021-03-22T10:30:07Z | |
| dc.date.issued | 2020-10 | |
| dc.identifier.issn | 15525260 (ISSN) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26760 | |
| dc.description.abstractEn | Introduction: We searched for consistent associations of an omega-3 index in plasma (sum of eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) with several dementia-related outcomes in a large cohort of older adults. Methods: We included 1279 participants from the Three-City study, non-demented at the time of blood measurements at baseline, with face-to-face neuropsychological assessment and systematic detection of incident dementia over a 17-year follow-up. An ancillary study included 467 participants with up to three repeated brain imaging exams over 10 years. Results: In multivariable models, higher levels of plasma EPA+DHA were consistently associated with a lower risk of dementia (hazard ratio for 1 standard deviation = 0.87 [95% confidence interval, 0.76–0.98]), and a lower decline in global cognition (P =.04 for change over time), memory (P =.06), and medial temporal lobe volume (P =.02). Discussion: This prospective study provides compelling evidence for a relationship between long-chain omega-3 fatty acids levels and lower risks for dementia and related outcomes. © 2020 the Alzheimer's Association | |
| dc.language.iso | EN | en_US |
| dc.title.en | Blood polyunsaturated omega‐3 fatty acids, brain atrophy, cognitive decline, and dementia risk | |
| dc.title.alternative | Alzheimers Dement | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/alz.12195 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 33090665 | en_US |
| bordeaux.journal | Alzheimer's and Dementia | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | SEPIA | en_US |
| bordeaux.team | BIOSTAT_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03176259 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-22T10:30:10Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20and%20Dementia&rft.date=2020-10&rft.eissn=15525260%20(ISSN)&rft.issn=15525260%20(ISSN)&rft.au=THOMAS,%20Aline&BAILLET,%20Marion&PROUST%20LIMA,%20Cecile&FEART-COURET,%20Catherine&SAMIER%20FOUBERT,%20Alexandra&rft.genre=article |
