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A Comparison of Cell Activation, Exhaustion, and Expression of HIV Coreceptors and Restriction Factors in HIV-1-and HIV-2-Infected Nonprogressors

dc.rights.licenseopenen_US
dc.contributor.authorDIALLO, M. S.
dc.contributor.authorSAMRI, A.
dc.contributor.authorCHARPENTIER, C.
dc.contributor.authorBERTINE, M.
dc.contributor.authorCHEYNIER, R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
dc.contributor.authorMATHERON, S.
dc.contributor.authorCOLLIN, F.
dc.contributor.authorBRAIBANT, M.
dc.contributor.authorCANDOTTI, D.
dc.contributor.authorBRUN-VEZINET, F.
dc.contributor.authorAUTRAN, B.
dc.date.accessioned2021-03-16T13:18:02Z
dc.date.available2021-03-16T13:18:02Z
dc.date.issued2020-11-12
dc.identifier.issn0889-2229en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26682
dc.description.abstractEnHuman immunodeficiency viruses induce rare attenuated diseases due either to HIV-1 in the exceptional long-term nonprogressors (LTNPs) or to HIV-2 in West Africa. To better understand characteristics of these two disease types we performed a multiplex comparative analysis of cell activation, exhaustion, and expression of coreceptors and restriction factors in CD4 T cells susceptible to harbor those viruses. We analyzed by flow cytometry the expression of HLA-DR, PD1, CCR5, CXCR6, SAMHD1, Blimp-1, and TRIM5 alpha on CD4 T cell subsets from 10 HIV-1(+) LTNPs and 14 HIV-2(+) (12 nonprogressors and 2 progressors) of the ANRS CO-15 and CO-5 cohorts, respectively, and 12 HIV- healthy donors (HD). The V3 loop of the HIV-1 envelope from 6 HIV-1+ LTNPs was sequenced to determine the CXCR6-binding capacity. Proportions of HLA-DR+ and PD1+ cells were higher in memory CD4 T subsets from HIV-1 LTNPs compared with HIV-2 and HD. Similar findings were observed for CCR5+ cells although limited to central-memory CD4 T cell (TCM) and follicular helper T cell subsets, whereas all major subsets from HIV-1 LTNPs contained less CXCR6+ cells compared with HIV-2. All six V3 loop sequences from HIV-1 LTNPs contained a proline at position 326. Proportions of SAMHD1+ cells were higher in all resting CD4 T subsets from HIV-1 LTNPs compared with the other groups, whereas Blimp-1+ and Trim5 alpha+ cells did not differ. The CD4 T cell subsets from HIV-1 LTNPs differ from those of HIV-2-infected subjects by higher levels of activation, exhaustion, and SAMHD1 expression that can reflect the distinct patterns of host/virus relationships.
dc.language.isoENen_US
dc.title.enA Comparison of Cell Activation, Exhaustion, and Expression of HIV Coreceptors and Restriction Factors in HIV-1-and HIV-2-Infected Nonprogressors
dc.title.alternativeAIDS Res Hum Retrovirusesen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1089/aid.2020.0084en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33050708en_US
bordeaux.journalAIDS Research and Human Retrovirusesen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSISTM_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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