The determinants of dyspnoea evaluated by the mMRC scale: The French Palomb cohort
| dc.rights.license | open | en_US |
| dc.contributor.author | OUAALAYA, El Hassane | |
| dc.contributor.author | FALQUE, L. | |
| dc.contributor.author | DUPIS, J. M. | |
| dc.contributor.author | SABATINI, M. | |
| dc.contributor.author | BERNADY, A. | |
| dc.contributor.author | NGUYEN, L. | |
| dc.contributor.author | OZIER, A. | |
| dc.contributor.author | NOCENT-EJNAINI, C. | |
| dc.contributor.author | LE GUILLOU, F. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MOLIMARD, Mathieu | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | RAHERISON-SEMJEN, Chantal | |
| dc.date.accessioned | 2021-03-15T15:41:26Z | |
| dc.date.available | 2021-03-15T15:41:26Z | |
| dc.date.issued | 2020-11-22 | |
| dc.identifier.issn | 2590-0412 (Electronic) 2590-0412 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26669 | |
| dc.description.abstractEn | INTRODUCTION AND OBJECTIVE: Dyspnoea is a major symptom in COPD patients, but the determinants that could be associated with a higher dyspnoea mMRC score in COPD patients remain unclear. Our research aimed to study the determinants of dyspnoea at the threshold of 1, 2, 3 and 4 mMRC. PATIENTS AND METHODS: Diagnosis of COPD was made using spirometry with post-bronchodilator FEV(1)FVC<70%. An online questionnaire has been employed by pulmonologists to recruit COPD patients. The following variables were collected: age, gender, BMI, FEV(1), RV, IC, TLC, FRC, mMRC, frequency of exacerbations and comorbidities. The LASSO was used to select the variables associated with the mMRC dyspnoea scale in a subgroup (who had no missing IC, RV and FRC values) of 421 COPD patients defined by the previously mentioned variables. RESULTS: One thousand nine hundred and sevety-three patients (65.3% males, average age=66±10, 38% current smokers) were included. Dyspnoea was correlated with a low FEV(1) and with the number of exacerbations in the past 12 months. Multivariate analysis showed that the determinants of dyspnoea(mMRC?2) are: FEV(1): OR=3.71[2.86-4.82]; anxiety: OR=2.52[1.82-3.47]; cough: OR=1.94[1.57-2.40]; bronchiectasis: OR=1.84[1.03-3.29]; age: OR=1.80[1.45-2.24]; hyperinflation (RV/TLC): OR=1.68[1.34-2.11]; ischemic cardiopathy: OR=1.63[1.22-2.18]; hypertension: OR=1.52[1.21-1.91]; exacerbations (?2): OR=1.41[1.10-1.81]; women: OR=1.39[1.10-1.74] and overweight: OR=1.33[1.06-1.67]. The subgroup analysis showed that: FEV(1): OR=3.47[1.96-6.12]; exacerbations (?2) OR=2.31[1.33-4.17] and hyperinflation (IC/TLC) OR=0.57[0.35-0.85] were associated with higher dyspnoea (mMRC?2). CONCLUSION: Our results showed that dyspnoea is related to the severity of airflow limitation, gender, exacerbations, comorbidities and hyperinflation. | |
| dc.language.iso | EN | en_US |
| dc.title.en | The determinants of dyspnoea evaluated by the mMRC scale: The French Palomb cohort | |
| dc.title.alternative | Respir Med Res | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.resmer.2020.100803 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 33326922 | en_US |
| bordeaux.journal | Respiratory Medicine and Research | en_US |
| bordeaux.page | 100803 | en_US |
| bordeaux.volume | 79 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | PharmacoEpi-Drugs | en_US |
| bordeaux.team | EPICENE_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03169818 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-15T15:41:32Z | |
| hal.export | true | |
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