Afficher la notice abrégée

Effect of changes in body mass index on the risk of cardiovascular disease and diabetes mellitus in HIV-positive individuals: results from the D: A: D study

dc.rights.licenseopenen_US
dc.contributor.authorPETOUMENOS, K.
dc.contributor.authorKUWANDA, L.
dc.contributor.authorRYOM, L.
dc.contributor.authorMOCROFT, A.
dc.contributor.authorREISS, P.
dc.contributor.authorDE WIT, S.
dc.contributor.authorPRADIER, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBONNET, Fabrice
dc.contributor.authorPHILLIPS, A.
dc.contributor.authorHATLEBERG, C. I.
dc.contributor.authorD'ARMINIO MONFORTE, A.
dc.contributor.authorWEBER, R.
dc.contributor.authorSABIN, C. A.
dc.contributor.authorLUNDGREN, J.
dc.contributor.authorLAW, M. G.
dc.date.accessioned2021-03-11T13:45:09Z
dc.date.available2021-03-11T13:45:09Z
dc.date.issued2020-12-17
dc.identifier.issn1944-7884 (Electronic) 1525-4135 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26645
dc.description.abstractEnBACKGROUND: Weight gain is common among people with HIV once antiretroviral treatment (ART) is commenced. We assess the effect of changes in body mass index (BMI), from different baseline BMI levels, on the risk of cardiovascular disease (CVD) and diabetes mellitus (DM). METHODS: D:A:D participants receiving ART were followed from their first BMI measurement to the first of either CVD or DM event, or earliest of 1/2/2016 or 6 months after last follow-up. Participants were stratified according to their baseline BMI, and changes from baseline BMI were calculated for each participant. Poisson regression models were used to assess the effects of changes on BMI on CVD or DM events. RESULTS: There were 2,104 CVD and 1,583 DM events over 365,287 and 354,898 person years (rate: CVD 5.8/1000 (95% CI 5.5-6.0); DM 4.5/1000 (95% CI 4.2 - 4.7)). Participants were largely male (74%), baseline mean age of 40 years and median BMI of 23.0 (IQR: 21.0-25.3). Risk of CVD by change in BMI from baseline, stratified by baseline BMI strata showed little evidence of an increased risk of CVD with an increased BMI in any baseline BMI strata. An increase in BMI was associated with an increased risk of DM across all baseline BMI strata. CONCLUSIONS: While increases in BMI across all levels of baseline BMI were not associated with an increased risk of CVD, such changes were consistently associated with increased risk of DM. There was also some evidence of an increased risk of CVD with a decrease in BMI.
dc.language.isoENen_US
dc.title.enEffect of changes in body mass index on the risk of cardiovascular disease and diabetes mellitus in HIV-positive individuals: results from the D: A: D study
dc.title.alternativeJ Acquir Immune Defic Syndren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qai.0000000000002603en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.journalJournal of Acquired Immune Deficiency Syndromesen_US
bordeaux.volumePublish Ahead of Printen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03166722
hal.version1
hal.date.transferred2021-03-11T13:45:13Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Acquired%20Immune%20Deficiency%20Syndromes&rft.date=2020-12-17&rft.volume=Publish%20Ahead%20of%20Print&rft.eissn=1944-7884%20(Electronic)%201525-4135%20(Linking)&rft.issn=1944-7884%20(Electronic)%201525-4135%20(Linking)&rft.au=PETOUMENOS,%20K.&KUWANDA,%20L.&RYOM,%20L.&MOCROFT,%20A.&REISS,%20P.&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée