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Statins use and risk of severe bacterial infection in a population living with HIV. Prospective cohort study of the ANRS CO3 Aquitaine Cohort 2000-2018

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTERUEL, Eva
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorVANDENHENDE, Marie-Anne
dc.contributor.authorNEAU, Didier
dc.contributor.authorLAZARO, Estibaliz
dc.contributor.authorDUFFAU, Pierre
dc.contributor.authorVAREIL, Marc Olivier
dc.contributor.authorCAZANAVE, Charles
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPERRIER, Adelaide
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLE MAREC, Fabien
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLELEUX, Olivier
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBONNET, Fabrice
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.date.accessioned2021-03-11T13:38:52Z
dc.date.available2021-03-11T13:38:52Z
dc.date.issued2021-09
dc.identifier.issn1469-0691 (Electronic) 1198-743X (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26643
dc.description.abstractEnObjectives: Bacterial infections remain one of the main causes of morbidity and death in people living with HIV (PLHIV) in the most recent years. Several studies have demonstrated a protective effect of statins in the primary prevention of bacterial infections in other immunocompromised populations, but this effect remains controversial. The objective of this study was to evaluate the effect of statin use on the occurrence of a first episode of severe bacterial infection (SBI) in PLHIV in the ANRS CO3 Aquitaine cohort between 2000 and 2018. Methods: All individuals included in the prospective ANRS CO3 Aquitaine cohort who had at least two follow-up visits between 2000 and 2018 were included. The primary endpoint was the occurrence of a first episode of bacterial infection leading to hospitalization of ≥48 hours or death. Statin exposure was updated during follow-up. Marginal Cox structural models were developed to consider the potential indication bias and time-dependent confusion. Numerous sensitivity analyses were carried out. Results: In this study 51 658 person-years were followed. The overall incidence of a first episode of SBI was 12.4/1000 person-years. No effect of statins on the occurrence of SBI was demonstrated when subjects were considered on statins throughout their follow-up after treatment initiation (HR = 0.97; 95%CI: 0.75–1.25). The results were similar for the effect of statins on the risk of pneumonia and for all sensitivity analyses. Conclusion: In this large cohort of PLHIV with 18 years of follow-up and a high risk of severe infections, we found no effect of statins on the risk of occurrence of SBI or pneumonia.
dc.language.isoENen_US
dc.subject.enBacterial infections
dc.subject.enHIV
dc.subject.enPneumonia
dc.subject.enRisk factor
dc.subject.enStatins
dc.title.enStatins use and risk of severe bacterial infection in a population living with HIV. Prospective cohort study of the ANRS CO3 Aquitaine Cohort 2000-2018
dc.title.alternativeClin Microbiol Infecten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.cmi.2020.11.019en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33276140en_US
bordeaux.journalClinical Microbiology and Infectionen_US
bordeaux.page1301-1307en_US
bordeaux.volume27
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03534117
hal.version1
hal.date.transferred2021-11-09T14:46:26Z
hal.exportfalse
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