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Influence of HLA-C environment on the spontaneous clearance of hepatitis C in European HIV-HCV co-infected individuals

dc.rights.licenseopenen_US
dc.contributor.authorLEGRAND, N.
dc.contributor.authorDAVID, G.
dc.contributor.authorRODALLEC, A.
dc.contributor.authorGAULTIER, A.
dc.contributor.authorSALMON, D.
dc.contributor.authorCESBRON, A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.contributor.authorRAFFI, F.
dc.contributor.authorGENDZEKHADZE, K.
dc.contributor.authorRETIERE, C.
dc.contributor.authorALLAVENA, C.
dc.contributor.authorGAGNE, K.
dc.date.accessioned2021-03-11T13:30:18Z
dc.date.available2021-03-11T13:30:18Z
dc.date.issued2020-12-12
dc.identifier.issn1365-2249 (Electronic) 0009-9104 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26640
dc.description.abstractEnNatural Killer (NK) cell functions are regulated by diverse inhibitory and activating receptors including Killer cell Immunoglobulin-like receptors (KIR) which interact with HLA class I molecules. Some KIR/HLA genetic combinations were reported associated with spontaneous clearance (SC) of hepatitis C virus (HCV) but with discordant results, possibly reflecting KIR and/or HLA gene polymorphism according to populations. KIR/HLA genetic combinations associated with both an exhaustive NK and T cell repertoire were investigated in a cohort of HIV-HCV co-infected individuals with either SC (n=68) or chronic infection (CI, n=163) compared to uninfected blood donors (Ctrl, n=100). Multivariate analysis showed that the HLA C2C2 environment was associated with SC only in European HIV-HCV co-infected individuals (OR=4.30[1.57-12.25], p=0.005). KIR2D(+) NK cell repertoire and potential of degranulation of KIR2DL1/S1(+) NK cells were similar in SC European cohort compared to uninfected individuals. In contrast, decreased frequencies of KIR2DS1(+) and KIR2DL2(+) NK cells were detected in CI group of Europeans compared to SC and a decreased frequency of KIR2DL1/S1(+) NK cells compared to controls. On the T cell side, higher frequencies of DNAM-1(+) and CD57(+) T cells were observed in SC in comparison to controls. Interestingly, SC subjects emphasized increased frequencies of KIR2DL2/L3/S2(+) T cells compared to CI subjects. Our study underlines that the C2 environment may activate efficient KIR2DL1(+) NK cells in viral context and maintain KIR2DL2/L3/S2(+) mature T cell response in the absence of KIR2DL2 engagement with its cognate ligands in SC group of HCV-HIV co-infected European patients.
dc.language.isoENen_US
dc.title.enInfluence of HLA-C environment on the spontaneous clearance of hepatitis C in European HIV-HCV co-infected individuals
dc.title.alternativeClin Exp Immunolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/cei.13562en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33314121en_US
bordeaux.journalClinical and Experimental Immunologyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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