A Low Level of Darunavir Resistance-Associated Mutation Emergence in Patients With Virological Failure During Long-term Use of Darunavir in People With HIV. The ANRS CO3 Aquitaine Cohort
| dc.rights.license | open | en_US |
| dc.contributor.author | CHAUSSADE, Helene | |
| dc.contributor.author | TUMIOTTO, Camille | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LE MAREC, Fabien | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LELEUX, Olivier | |
| dc.contributor.author | LEFEVRE, Lucile | |
| dc.contributor.author | LAZARO, Estibaliz | |
| dc.contributor.author | LAFON, Marie-Edith | |
| dc.contributor.author | NYAMANKOLLY, Elsa | |
| dc.contributor.author | DUFFAU, Pierre | |
| dc.contributor.author | NEAU, Didier | |
| dc.contributor.author | BELLECAVE, Pantxika | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BONNET, Fabrice | |
| dc.date.accessioned | 2021-03-11T13:22:35Z | |
| dc.date.available | 2021-03-11T13:22:35Z | |
| dc.date.issued | 2020-12 | |
| dc.identifier.issn | 2328-8957 (Print) 2328-8957 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26639 | |
| dc.description.abstractEn | BACKGROUND: Ritonavir-boosted darunavir (DRV/r) is a protease inhibitor (PI) indicated for the treatment of na�ve and pretreated HIV-infected patients since 2007. Our study aims to describe DRV/r-treated patients experiencing virological failure (VF) documented with HIV resistance testing. METHODS: Data from patients belonging to the ANRS CO3 Aquitaine Cohort treated with a regimen including DRV/r between February 2007 and December 2015 were analyzed. Baseline characteristics of patients experiencing VF (defined by 2 consecutive plasma viral loads >50 copies/mL) were compared with those without VF. We then described factors associated with VF as emergence of IAS DRV resistance-associated mutations (RAMs). RESULTS: Among the 1458 patients treated at least once with a DRV/r-based regimen, 270 (18.5%) patients experienced VF during follow-up, including 240 with at least 1 genotype resistance test (GRT). DRV RAMs were detected in 29 patients (12%). Among them, 25/29 patients had ?2 DRV RAMs before DRV/r initiation, all of whom had experienced VF during previous PI treatments. For 18/29, DRV/r was maintained after VF, and controlled viremia was restored after modification of DRV-associated antiretroviral molecules or increased DRV dose. Finally, only 6/29 patients selected new DRV RAMs after DRV/r initiation. All of these experienced previous VFs while on other PIs. CONCLUSIONS: These results highlight the efficacy and robustness of DRV/r, as the emergence of DRV RAMs appeared in <0.4% of patients receiving a DRV/r-based regimen in our large cohort. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.title.en | A Low Level of Darunavir Resistance-Associated Mutation Emergence in Patients With Virological Failure During Long-term Use of Darunavir in People With HIV. The ANRS CO3 Aquitaine Cohort | |
| dc.title.alternative | Open Forum Infect Dis | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/ofid/ofaa567 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| bordeaux.journal | Open Forum Infectious Diseases | en_US |
| bordeaux.volume | 7 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 12 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | MORPH3Eus | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03166658 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-11T13:22:39Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Open%20Forum%20Infectious%20Diseases&rft.date=2020-12&rft.volume=7&rft.issue=12&rft.eissn=2328-8957%20(Print)%202328-8957&rft.issn=2328-8957%20(Print)%202328-8957&rft.au=CHAUSSADE,%20Helene&TUMIOTTO,%20Camille&LE%20MAREC,%20Fabien&LELEUX,%20Olivier&LEFEVRE,%20Lucile&rft.genre=article |
