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Mortality in relation to hepatitis B virus (HBV) infection status among HIV-HBV co-infected patients in sub-Saharan Africa after immediate initiation of antiretroviral therapy

dc.rights.licenseopenen_US
dc.contributor.authorMOHAREB, A. M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorKOUAME, Menan Gerard
dc.contributor.authorGABASSI, A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGABILLARD, Delphine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOH, Desmorys Raoul
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBADJE, Anani Dodzi
dc.contributor.authorEMIEME, A.
dc.contributor.authorMAYLIN, S.
dc.contributor.authorMENAN, H.
dc.contributor.authorHYLE, E. P.
dc.contributor.authorDELAUGERRE, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDANEL, Christine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorANGLARET, Xavier
dc.contributor.authorLACOMBE, K.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorEHOLIE, Serge Paul
dc.contributor.authorBOYD, A.
dc.date.accessioned2021-03-08T11:15:39Z
dc.date.available2021-03-08T11:15:39Z
dc.date.issued2020-12-31
dc.identifier.issn1365-2893 (Electronic) 1352-0504 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26454
dc.description.abstractEnBACKGROUND: It is unknown how past and active hepatitis B virus (HBV) infection affect immunorecovery and mortality in people with HIV who initiate tenofovir-based anti-retroviral therapy (ART). METHODS: Using data collected between 2008- 2015, we studied people with HIV in sub-Saharan Africa initiating immediate ART in the Temprano randomized control trial. We classified participants into HBV groups at ART-initiation: hepatitis B surface antigen (HBsAg)-positive with HBV DNA ≥2000 IU/mL; HBsAg-positive with HBV DNA <2000 IU/ml; isolated HBcAb-positive; resolved infection (HBsAb-positive/HBcAb-positive); and HBV non-immune/vaccinated (HBcAb-). We compared square-root CD4-cell count increases using a mixed-effect, non-linear regression adjusted for age, sex, baseline CD4 cell count, and HIV RNA. We compared all-cause mortality using Bayesian parametric survival regression. RESULTS: Among 879 participants, 24 (2.7%) had HBsAg with high HBV DNA, 76 (8.6%) HBsAg with low HBV DNA, 325 (37.0%) isolated anti-HBcAb, 226 (25.7%) resolved HBV infection, and 228 (25.9%) HBV non-immune/vaccinated. We found no significant difference in CD4 cell increases between the four HBV-infection groups after adjustment (p=0.16). Participants with HBsAg and high HBV DNA had the highest incidence of all-cause mortality [1.9/100 person-years, 95%Credibile Interval (CrI)=1.0-3.4]. By comparison, incidence rates of mortality were reduced by 57% (95%CrI=-79%,-13%), 60% (95%CrI=-82%,-12%), and 66% (95%CrI=-84%,-23%) in those who had isolated anti-HBcAb-positive, resolved HBV infection, and HBV non-immune/vaccinated, respectively. CONCLUSION: Individuals with HIV and past HBV infection or isolated anti-HBcAb-positive serology, much like HBV non-immune/vaccinated, experience lower mortality than those with HBsAg and high HBV DNA. Additional HBV-related management would not be necessary for these individuals.
dc.language.isoENen_US
dc.title.enMortality in relation to hepatitis B virus (HBV) infection status among HIV-HBV co-infected patients in sub-Saharan Africa after immediate initiation of antiretroviral therapy
dc.title.alternativeJ Viral Hepaten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/jvh.13461en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33382189en_US
bordeaux.journalJournal of Viral Hepatitisen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamIDLICen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20Viral%20Hepatitis&amp;rft.date=2020-12-31&amp;rft.eissn=1365-2893%20(Electronic)%201352-0504%20(Linking)&amp;rft.issn=1365-2893%20(Electronic)%201352-0504%20(Linking)&amp;rft.au=MOHAREB,%20A.%20M.&amp;KOUAME,%20Menan%20Gerard&amp;GABASSI,%20A.&amp;GABILLARD,%20Delphine&amp;MOH,%20Desmorys%20Raoul&amp;rft.genre=article


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