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A highly sensitive UHPLC-MS/MS method for urine biological monitoring of occupational exposure to anthracycline antineoplastic drugs and routine application

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorVILLA, Antoine
dc.contributor.authorTREMOLET, K.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMARTINEZ, Beatrice
dc.contributor.authorDA SILVA CACAO, O.
dc.contributor.authorATGE, B.
dc.contributor.authorDUCINT, D.
dc.contributor.authorTITIER-DEBEAUPUIS, K.
dc.contributor.authorVERDUN-ESQUER, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOLIMARD, Mathieu
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCANAL-RAFFIN, Mireille
dc.date.accessioned2021-03-04T09:40:23Z
dc.date.available2021-03-04T09:40:23Z
dc.date.issued2020-11-01
dc.identifier.issn1873-376X (Electronic) 1570-0232 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26417
dc.description.abstractEnAnthracycline antineoplastic drugs (doxorubicin, epirubicin, daunorubicin) are "hazardous drugs for handling" by healthcare professionals. To monitor their occupational exposure, a highly sensitive ESI-UHPLC-MS/MS method for the assay of anthracyclines in urine was developed. The urine extraction consisted of SPE extraction method. A good linearity (r > 0.996), precision (CV < 14.4%), and accuracy (bias < 13.6%) were achieved for the three drugs. The lower limit of quantification (LOQ) was 10 ng/L. This LOQ value is equal to the LOQ of published methods except for epirubicin, for which the LOQ value is better by a factor of 10 (best published LOQ value: 100 ng/L). Applying this method in routine, more than 77 healthcare professionals occupationally exposed to anthracyclines were monitored and 77 urines were analyzed. Two healthcare professionals (2.6%) were found to be contaminated to doxorubicin and/or epirubicin. The measured concentrations ranged from 17.7 to 218 ng/L. Such an efficient analytical tool, combining both high specificity and sensitivity is essential for reliable highlight of contamination during biological monitoring of healthcare professionals widely exposed to these drugs. This anthracycline antineoplastic drugs exposure monitoring allows healthcare professionals for assessing effectiveness individual and collective protective measures and for ensuring traceability of occupational exposure to these drugs.
dc.language.isoENen_US
dc.title.enA highly sensitive UHPLC-MS/MS method for urine biological monitoring of occupational exposure to anthracycline antineoplastic drugs and routine application
dc.title.alternativeJ Chromatogr B Analyt Technol Biomed Life Scien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jchromb.2020.122305en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32987297en_US
bordeaux.journalJournal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciencesen_US
bordeaux.page122305en_US
bordeaux.volume1156en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teampharmacoEpi-Drugsen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03158862
hal.version1
hal.date.transferred2021-03-04T09:40:27Z
hal.exporttrue
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