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Occupational exposure to unintentionally emitted nanoscale particles and risk of cancer: From lung to central nervous system - Results from three French case-control studies

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMANANGAMA, Guyguy
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGRAMOND, Celine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAUDIGNON-DURAND, Sabyne
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBALDI, Isabelle
dc.contributor.authorFABRO-PERAY, P.
dc.contributor.authorGILG SOIT ILG, A.
dc.contributor.authorGUENEL, P.
dc.contributor.authorLEBAILLY, Pierre
dc.contributor.authorLUCE, D.
dc.contributor.authorSTUCKER, I.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBROCHARD, Patrick
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLACOURT, Aude
dc.date.accessioned2021-03-04T09:21:16Z
dc.date.available2021-03-04T09:21:16Z
dc.date.issued2020-12
dc.identifier.issn1096-0953 (Electronic) 0013-9351 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26414
dc.description.abstractEnOBJECTIVES: Nanoscale particles (1-100 nm) can be of natural origin, and either intentionally or unintentionally produced by human activities. Toxicological data have suggested a possible carcinogenic effect of such particles. The aim of this study was to estimate the association between occupational exposure to nanoscale particles and risk of lung cancer, pleural mesothelioma and brain tumors in adults. METHODS: Three French population-based case-control studies were analyzed: 1) the ICARE study including 2,029 lung cancer cases and 2,591 controls; 2) the PNSM study including 371 pleural mesothelioma cases and 730 controls and 3) the CERENAT study including 257 brain tumor cases and 511 controls. Occupational exposure to unintentionally emitted nanoscale particles (UNPs) was retrospectively assessed by a job exposure matrix providing a probability and a frequency of exposure. RESULTS: In adjusted analyses among men, significant associations between occupational exposure to UNPs and lung cancer (OR=1.51; 95% CI: 1.22-1.86 and brain tumors (OR=1.69; 95% CI: 1.17-2.44) were observed. No increased OR was observed for pleural mesothelioma (OR=0.78; 95% CI: 0.46-1.33). CONCLUSION: This is the first study showing positive associations between occupational exposure to UNPs and increased risk of lung cancer and brain tumors. These preliminary results should encourage further epidemiological research.
dc.language.isoENen_US
dc.title.enOccupational exposure to unintentionally emitted nanoscale particles and risk of cancer: From lung to central nervous system - Results from three French case-control studies
dc.title.alternativeEnviron Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.envres.2020.110024
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32777272en_US
bordeaux.journalEnvironmental Researchen_US
bordeaux.page110024en_US
bordeaux.volume191en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03162383
hal.version1
hal.date.transferred2021-03-08T13:37:36Z
hal.exporttrue
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