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Short-term blood pressure variability, arterial stiffness, and cardiovascular events: results from the Bordeaux cohort

dc.rights.licenseopenen_US
dc.contributor.authorCREMER, A.
dc.contributor.authorDOUBLET, J.
dc.contributor.authorBOULESTREAU, R.
dc.contributor.authorGAUDISSARD, J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
IDREF: 69829209
dc.contributor.authorGOSSE, P.
dc.date.accessioned2021-03-01T13:09:25Z
dc.date.available2021-03-01T13:09:25Z
dc.date.issued2021-01-07
dc.identifier.issn0263-6352en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26383
dc.description.abstractEnOBJECTIVE: Short-term blood pressure variability derived from 24-h ambulatory monitoring is associated with poor cardiovascular prognosis. However, previous analyses of this have clearly been influenced by clinical cofounders, particularly blood pressure (BP) level. Arterial stiffness is a powerful marker of cardiovascular risk, which may influence BP variability. In this study, we assessed the prognostic value of BP variability based on 24-h ambulatory measurements and adjusted for arterial stiffness. METHODS: Population: Bordeaux cohort of hypertensive patients. Inclusion criteria were 24-h ambulatory BP monitoring at baseline with measurements every 15' day and night, determination of wake-up time and bedtime, and assessment of arterial stiffness with monitoring of Korotkoff sound arrival time. A total of 969 patients (age 54 ± 14 years) with an average follow up of 120 ± 78 months and 178 cardiovascular recorded events were included. RESULTS: In univariate survival analyses, the standard deviations of day, night, and 24-h SBP were associated with the occurrence of cardiovascular events. The standard deviation of night-time SBP showed the strongest association with the outcome variable and was entered into multivariate analyses. In multivariate analyses, night-time SBP variability remained significantly associated with the occurrence of cardiovascular events after adjusting for major cardiovascular risk factors, 24-h SBP, and arterial stiffness. BP variability and arterial stiffness showed no significant association. CONCLUSION: Our results suggest that variability of night-time SBP is an important marker of the risk of cardiovascular events in hypertensive patients, independently of average 24-h BP and arterial stiffness.
dc.language.isoENen_US
dc.title.enShort-term blood pressure variability, arterial stiffness, and cardiovascular events: results from the Bordeaux cohort
dc.title.alternativeJ Hypertensen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/hjh.0000000000002735en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33427788en_US
bordeaux.journalJournal of Hypertensionen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03154964
hal.version1
hal.date.transferred2021-03-01T13:09:28Z
hal.exporttrue
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