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Association of Plasma Soluble Vascular Cell Adhesion Molecule-1 and sCD14 With Mortality in HIV-1-Infected West African Adults With High CD4 Counts

dc.rights.licenseopenen_US
dc.contributor.authorAFFI, R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGABILLARD, Delphine
dc.contributor.authorDUNYACH-REMY, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorNTAKPE, Jean-Baptiste
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOH, Desmorys Raoul
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBADJE, Anani Dodzi
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorKOUAME, Menan Gerard
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorKARCHER, Sophie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLE CARROU, Jérôme
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDANEL, Christine
dc.contributor.authorCHEVALIER, M. F.
dc.contributor.authorROUZIOUX, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorEHOLIE, Serge P.
dc.contributor.authorLAVIGNE, J. P.
dc.contributor.authorINWOLEY, A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorANGLARET, Xavier
dc.contributor.authorWEISS, L.
dc.date.accessioned2021-03-01T08:24:45Z
dc.date.available2021-03-01T08:24:45Z
dc.date.issued2021-01-01
dc.identifier.issn1944-7884 (Electronic) 1525-4135 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26367
dc.description.abstractEnBACKGROUND: Several biomarkers of inflammation and coagulation were reported to be associated with HIV disease progression in different settings. Here we report the association between eleven biomarkers and medium-term mortality in HIV-infected West Africa adults. METHODS: In Temprano ANRS 12136, ART-naïve HIV-infected adults with high CD4 counts were randomly assigned either to start ART immediately or defer ART until the WHO criteria were met. Participants who completed the 30-month trial follow-up were invited to participate in a post-trial phase (PTP). The PTP endpoint was all-cause death. We used multivariate Cox proportional models to analyze the association between baseline plasma biomarkers (IL-1ra, IL-6, sVCAM-1, sCD14, D-dimer, Fibrinogen, IP-10, sCD163, albumin, hsCRP, 16S rDNA) and all-cause death in the Temprano participants randomized to defer ART. RESULTS: 477 patients (median age 35, 78% women, median CD4 count: 379 cells/mm) were randomly assigned to defer starting ART until the WHO criteria were met. The participants were followed for 2646 person-years (median 5.8 years). In the follow-up, 89% of participants started ART and 30 died. In the multivariate analysis adjusted for the study center, sex, baseline CD4 count, isoniazid preventive therapy, plasma HIV-1 RNA, PBMC HIV-1 DNA and ART, the risk of death was significantly associated with baseline sVCAM-1 (≥ 1458 vs. < 1458: adjusted hazard ratio [aHR] 2.57, 95% CI 1.13-5.82) and sCD14 (≥ 2187 vs. < 2187: aHR 2.79, IQR 1.29-6.02) levels. CONCLUSION: In these sub-Saharan African adults with high CD4 counts, pre-ART plasma sVCAM-1 and sCD14 levels were independently associated with mortality.
dc.language.isoENen_US
dc.title.enAssociation of Plasma Soluble Vascular Cell Adhesion Molecule-1 and sCD14 With Mortality in HIV-1-Infected West African Adults With High CD4 Counts
dc.title.alternativeJ Acquir Immune Defic Syndren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qai.0000000000002533en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.journalJournal of Acquired Immune Deficiency Syndromesen_US
bordeaux.page138-145en_US
bordeaux.volume86en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamIDLICen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03165510
hal.version1
hal.date.transferred2021-03-10T15:40:22Z
hal.exporttrue
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