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Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes

dc.rights.licenseopenen_US
dc.contributor.authorSHIN, J.
dc.contributor.authorMA, S.
dc.contributor.authorHOFER, E.
dc.contributor.authorPATEL, Y.
dc.contributor.authorVOSBERG, D. E.
dc.contributor.authorTILLEY, S.
dc.contributor.authorROSHCHUPKIN, G. V.
dc.contributor.authorSOUSA, A. M. M.
dc.contributor.authorJIAN, X.
dc.contributor.authorGOTTESMAN, R.
dc.contributor.authorMOSLEY, T. H.
dc.contributor.authorFORNAGE, M.
dc.contributor.authorSABA, Y.
dc.contributor.authorPIRPAMER, L.
dc.contributor.authorSCHMIDT, R.
dc.contributor.authorSCHMIDT, H.
dc.contributor.authorCARRION-CASTILLO, A.
dc.contributor.authorCRIVELLO, F.
dc.contributor.authorMAZOYER, Bernard
dc.contributor.authorBIS, J. C.
dc.contributor.authorLI, S.
dc.contributor.authorYANG, Q.
dc.contributor.authorLUCIANO, M.
dc.contributor.authorKARAMA, S.
dc.contributor.authorLEWIS, L.
dc.contributor.authorBASTIN, M. E.
dc.contributor.authorHARRIS, M. A.
dc.contributor.authorWARDLAW, J. M.
dc.contributor.authorDEARY, I. E.
dc.contributor.authorSCHOLZ, M.
dc.contributor.authorLOEFFLER, M.
dc.contributor.authorWITTE, A. V.
dc.contributor.authorBEYER, F.
dc.contributor.authorVILLRINGER, A.
dc.contributor.authorARMSTRONG, N. J.
dc.contributor.authorMATHER, K. A.
dc.contributor.authorAMES, D.
dc.contributor.authorJIANG, J.
dc.contributor.authorKWOK, J. B.
dc.contributor.authorSCHOFIELD, P. R.
dc.contributor.authorTHALAMUTHU, A.
dc.contributor.authorTROLLOR, J. N.
dc.contributor.authorWRIGHT, M. J.
dc.contributor.authorBRODATY, H.
dc.contributor.authorWEN, W.
dc.contributor.authorSACHDEV, P. S.
dc.contributor.authorTERZIKHAN, N.
dc.contributor.authorEVANS, T. E.
dc.contributor.authorADAMS, Hhhh
dc.contributor.authorIKRAM, M. A.
dc.contributor.authorFRENZEL, S.
dc.contributor.authorAUWERA-PALITSCHKA, S. V.
dc.contributor.authorWITTFELD, K.
dc.contributor.authorBULOW, R.
dc.contributor.authorGRABE, H. J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMISHRA, Aniket
dc.contributor.authorMAINGAULT, S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorGILLESPIE, N. A.
dc.contributor.authorFRANZ, C. E.
dc.contributor.authorKREMEN, W. S.
dc.contributor.authorDING, L.
dc.contributor.authorJAHANSHAD, N.
dc.contributor.authorSESTAN, N.
dc.contributor.authorPAUSOVA, Z.
dc.contributor.authorSESHADRI, Sudha
dc.contributor.authorPAUS, T.
dc.date.accessioned2021-02-26T11:11:12Z
dc.date.available2021-02-26T11:11:12Z
dc.date.issued2020
dc.identifier.issn1460-2199 (Electronic) 1047-3211 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26364
dc.description.abstractEnWe have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade—albeit in a very limited manner—to behaviors as complex as the choice of one’s occupation.
dc.language.isoENen_US
dc.subjectVINTAGE
dc.title.enGlobal and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes
dc.title.alternativeCereb Cortexen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/cercor/bhaa035en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32198502en_US
bordeaux.journalCerebral Cortexen_US
bordeaux.page4121-4139en_US
bordeaux.volume30en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamVINTAGEen_US
bordeaux.teamHEALTHY_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03153357
hal.version1
hal.date.transferred2021-02-26T11:11:20Z
hal.exporttrue
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