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An investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis

dc.rights.licenseopenen_US
dc.contributor.authorPETERS, R.
dc.contributor.authorYASAR, S.
dc.contributor.authorANDERSON, C. S.
dc.contributor.authorANDREWS, S.
dc.contributor.authorANTIKAINEN, R.
dc.contributor.authorARIMA, H.
dc.contributor.authorBECKETT, N.
dc.contributor.authorBEER, J. C.
dc.contributor.authorBERTENS, A. S.
dc.contributor.authorBOOTH, A.
dc.contributor.authorVAN BOXTEL, M.
dc.contributor.authorBRAYNE, C.
dc.contributor.authorBRODATY, H.
dc.contributor.authorCARLSON, M. C.
dc.contributor.authorCHALMERS, J.
dc.contributor.authorCORRADA, M.
dc.contributor.authorDEKOSKY, S.
dc.contributor.authorDERBY, C.
dc.contributor.authorDIXON, R. A.
dc.contributor.authorFORETTE, F.
dc.contributor.authorGANGULI, M.
dc.contributor.authorVAN GOOL, W. A.
dc.contributor.authorGUAITA, A.
dc.contributor.authorHEVER, A. M.
dc.contributor.authorHOGAN, D. B.
dc.contributor.authorJAGGER, C.
dc.contributor.authorKATZ, M.
dc.contributor.authorKAWAS, C.
dc.contributor.authorKEHOE, P. G.
dc.contributor.authorKEINANEN-KIUKAANNIEMI, S.
dc.contributor.authorKENNY, R. A.
dc.contributor.authorKOHLER, S.
dc.contributor.authorKUNUTSOR, S. K.
dc.contributor.authorLAUKKANEN, J.
dc.contributor.authorMAXWELL, C.
dc.contributor.authorMCFALL, G. P.
dc.contributor.authorVAN MIDDELAAR, T.
dc.contributor.authorMOLL VAN CHARANTE, E. P.
dc.contributor.authorNG, T. P.
dc.contributor.authorPETERS, J.
dc.contributor.authorRAWTAER, I.
dc.contributor.authorRICHARD, E.
dc.contributor.authorROCKWOOD, K.
dc.contributor.authorRYDEN, L.
dc.contributor.authorSACHDEV, P. S.
dc.contributor.authorSKOOG, I.
dc.contributor.authorSKOOG, J.
dc.contributor.authorSTAESSEN, J. A.
dc.contributor.authorSTEPHAN, B. C. M.
dc.contributor.authorSEBERT, S.
dc.contributor.authorTHIJS, L.
dc.contributor.authorTROMPET, S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTULLY, Phillip J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
dc.contributor.authorVACCARO, R.
dc.contributor.authorVAARAMO, E.
dc.contributor.authorWALSH, E.
dc.contributor.authorWARWICK, J.
dc.contributor.authorANSTEY, K. J.
dc.date.accessioned2021-02-25T13:37:48Z
dc.date.available2021-02-25T13:37:48Z
dc.date.issued2020
dc.identifier.issn1526-632X (Electronic) 0028-3878 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26352
dc.description.abstractEnObjective High blood pressure is one of the main modifiable risk factors for dementia. However, there is conflicting evidence regarding the best antihypertensive class for optimizing cognition. Our objective was to determine whether any particular antihypertensive class was associated with a reduced risk of cognitive decline or dementia using comprehensive meta-analysis including reanalysis of original participant data. Methods To identify suitable studies, MEDLINE, Embase, and PsycINFO and preexisting study consortia were searched from inception to December 2017. Authors of prospective longitudinal human studies or trials of antihypertensives were contacted for data sharing and collaboration. Outcome measures were incident dementia or incident cognitive decline (classified using the reliable change index method). Data were separated into mid and late-life (>65 years) and each antihypertensive class was compared to no treatment and to treatment with other antihypertensives. Meta-analysis was used to synthesize data. Results Over 50,000 participants from 27 studies were included. Among those aged >65 years, with the exception of diuretics, we found no relationship by class with incident cognitive decline or dementia. Diuretic use was suggestive of benefit in some analyses but results were not consistent across follow-up time, comparator group, and outcome. Limited data precluded meaningful analyses in those ≤65 years of age. Conclusion Our findings, drawn from the current evidence base, support clinical freedom in the selection of antihypertensive regimens to achieve blood pressure goals.
dc.language.isoENen_US
dc.subjectHEALTHY
dc.title.enAn investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis
dc.title.alternativeNeurologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1212/wnl.0000000000008732en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31827004en_US
bordeaux.journalNeurologyen_US
bordeaux.pagee267-e281en_US
bordeaux.volume94en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03152263
hal.version1
hal.date.transferred2021-02-25T13:37:56Z
hal.exporttrue
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