Afficher la notice abrégée

Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan

dc.rights.licenseopenen_US
dc.contributor.authorPARKER, N.
dc.contributor.authorVIDAL-PINEIRO, D.
dc.contributor.authorFRENCH, L.
dc.contributor.authorSHIN, J.
dc.contributor.authorADAMS, H. H. H.
dc.contributor.authorBRODATY, H.
dc.contributor.authorCOX, S. R.
dc.contributor.authorDEARY, I. J.
dc.contributor.authorFJELL, A. M.
dc.contributor.authorFRENZEL, S.
dc.contributor.authorGRABE, H.
dc.contributor.authorHOSTEN, N.
dc.contributor.authorIKRAM, M. A.
dc.contributor.authorJIANG, J.
dc.contributor.authorKNOL, M. J.
dc.contributor.authorMAZOYER, Bernard
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMISHRA, Aniket
dc.contributor.authorSACHDEV, P. S.
dc.contributor.authorSALUM, G.
dc.contributor.authorSATIZABAL, C. L.
dc.contributor.authorSCHMIDT, H.
dc.contributor.authorSCHMIDT, R.
dc.contributor.authorSESHADRI, Sudha
dc.contributor.authorSCHUMANN, G.
dc.contributor.authorVOLZKE, H.
dc.contributor.authorWALHOVD, K. B.
dc.contributor.authorWEN, W.
dc.contributor.authorWITTFELD, K.
dc.contributor.authorYANG, Q.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorPAUSOVA, Z.
dc.contributor.authorPAUS, T.
dc.date.accessioned2021-02-25T10:53:42Z
dc.date.available2021-02-25T10:53:42Z
dc.date.issued2020
dc.identifier.issn1460-2199 (Electronic) 1047-3211 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26347
dc.description.abstractEnExposures to life stressors accumulate across the lifespan, with possible impact on brain health. Little is known, however, about the mechanisms mediating age-related changes in brain structure. We use a lifespan sample of participants (n = 21 251; 4–97 years) to investigate the relationship between the thickness of cerebral cortex and the expression of the glucocorticoid- and the mineralocorticoid-receptor genes (NR3C1 and NR3C2, respectively), obtained from the Allen Human Brain Atlas. In all participants, cortical thickness correlated negatively with the expression of both NR3C1 and NR3C2 across 34 cortical regions. The magnitude of this correlation varied across the lifespan. From childhood through early adulthood, the profile similarity (between NR3C1/NR3C2 expression and thickness) increased with age. Conversely, both profile similarities decreased with age in late life. These variations do not reflect age-related changes in NR3C1 and NR3C2 expression, as observed in 5 databases of gene expression in the human cerebral cortex (502 donors). Based on the co-expression of NR3C1 (and NR3C2) with genes specific to neural cell types, we determine the potential involvement of microglia, astrocytes, and CA1 pyramidal cells in mediating the relationship between corticosteroid exposure and cortical thickness. Therefore, corticosteroids may influence brain structure to a variable degree throughout life.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectVINTAGE
dc.title.enCorticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan
dc.title.alternativeCereb Cortexen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/cercor/bhz108en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31240317en_US
bordeaux.journalCerebral Cortexen_US
bordeaux.page575-586en_US
bordeaux.volume30en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamVINTAGEen_US
bordeaux.teamHEALTHY_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03152080
hal.version1
hal.date.transferred2021-02-25T10:53:55Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cerebral%20Cortex&rft.date=2020&rft.volume=30&rft.issue=2&rft.spage=575-586&rft.epage=575-586&rft.eissn=1460-2199%20(Electronic)%201047-3211%20(Linking)&rft.issn=1460-2199%20(Electronic)%201047-3211%20(Linking)&rft.au=PARKER,%20N.&VIDAL-PINEIRO,%20D.&FRENCH,%20L.&SHIN,%20J.&ADAMS,%20H.%20H.%20H.&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
BPH_CC_2020_Parker.pdf
Taille:
826.1Ko
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
license_rdf
Taille:
914octets
Format:
application/rdf+xml
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée