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Artery occlusion independently predicts unfavorable outcome in cervical artery dissection

dc.rights.licenseopenen_US
dc.contributor.authorTRAENKA, C.
dc.contributor.authorGROND-GINSBACH, C.
dc.contributor.authorGOEGGEL SIMONETTI, B.
dc.contributor.authorMETSO, T. M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorPEZZINI, A.
dc.contributor.authorKLOSS, M.
dc.contributor.authorMAJERSIK, J. J.
dc.contributor.authorSOUTHERLAND, A. M.
dc.contributor.authorLEYS, D.
dc.contributor.authorBAUMGARTNER, R.
dc.contributor.authorCASO, V.
dc.contributor.authorBEJOT, Y.
dc.contributor.authorDE MARCHIS, G. M.
dc.contributor.authorFISCHER, U.
dc.contributor.authorPOLYMERIS, A.
dc.contributor.authorSARIKAYA, H.
dc.contributor.authorTHIJS, V.
dc.contributor.authorWORRALL, B. B.
dc.contributor.authorBERSANO, A.
dc.contributor.authorBRANDT, T.
dc.contributor.authorGENSICKE, H.
dc.contributor.authorBONATI, L. H.
dc.contributor.authorTOUZEE, E.
dc.contributor.authorMARTIN, J. J.
dc.contributor.authorCHABRIAT, H.
dc.contributor.authorTATLISUMAK, T.
dc.contributor.authorARNOLD, M.
dc.contributor.authorENGELTER, S. T.
dc.contributor.authorLYRER, P.
dc.date.accessioned2021-02-23T13:53:42Z
dc.date.available2021-02-23T13:53:42Z
dc.date.issued2020
dc.identifier.issn1526-632X (Electronic) 0028-3878 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26325
dc.description.abstractEnObjective To assess the impact of dissected artery occlusion (DAO) on functional outcome and complications in patients with cervical artery dissection (CeAD). Methods We analyzed combined individual patient data from 3 multicenter cohorts of consecutive patients with CeAD (the Cervical Artery Dissection and Ischemic Stroke Patients [CADISP]–Plus consortium dataset). Patients with data on DAO and functional outcome were included. We compared patients with DAO to those without DAO. Primary outcome was favorable functional outcome (i.e., modified Rankin Scale [mRS] score 0–1) measured 3–6 months from baseline. Secondary outcomes included delayed cerebral ischemia, major hemorrhage, recurrent CeAD, and death. We performed univariate and multivariable binary logistic regression analyses and calculated odds ratios (OR) with 95% confidence intervals (CI), with adjustment for potential confounders. Results Of 2,148 patients (median age 45 years [interquartile range (IQR) 38–52], 43.6% women), 728 (33.9%) had DAO. Patients with DAO more frequently presented with cerebral ischemia (84.6% vs 58.5%, p < 0.001). Patients with DAO were less likely to have favorable outcome when compared to patients without DAO (mRS 0–1: 59.6% vs 80.1%, punadjusted < 0.001). After adjustment for age, sex, and initial stroke severity, DAO was independently associated with less favorable outcome (mRS 0–1: OR 0.65, CI 0.50–0.84, p = 0.001). Delayed cerebral ischemia occurred more frequently in patients with DAO than in patients without DAO (4.5% vs 2.9%, p = 0.059). Conclusion DAO independently predicts less favorable functional outcome in patients with CeAD. Further research on vessel patency, collateral status and effects of revascularization therapies particularly in patients with DAO is warranted.
dc.language.isoENen_US
dc.subjectVINTAGE
dc.title.enArtery occlusion independently predicts unfavorable outcome in cervical artery dissection
dc.title.alternativeNeurologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1212/wnl.0000000000008654en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31757869en_US
bordeaux.journalNeurologyen_US
bordeaux.pagee170-e180en_US
bordeaux.volume94en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03150070
hal.version1
hal.date.transferred2021-02-23T13:53:47Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Neurology&amp;rft.date=2020&amp;rft.volume=94&amp;rft.issue=2&amp;rft.spage=e170-e180&amp;rft.epage=e170-e180&amp;rft.eissn=1526-632X%20(Electronic)%200028-3878%20(Linking)&amp;rft.issn=1526-632X%20(Electronic)%200028-3878%20(Linking)&amp;rft.au=TRAENKA,%20C.&amp;GROND-GINSBACH,%20C.&amp;GOEGGEL%20SIMONETTI,%20B.&amp;METSO,%20T.%20M.&amp;DEBETTE,%20Stephanie&amp;rft.genre=article


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