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The genetic history of France

dc.rights.licenseopenen_US
dc.contributor.authorSAINT PIERRE, A.
dc.contributor.authorGIEMZA, J.
dc.contributor.authorALVES, I.
dc.contributor.authorKARAKACHOFF, M.
dc.contributor.authorGAUDIN, M.
dc.contributor.authorAMOUYEL, Philippe
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
dc.contributor.authorMONTEIL, M.
dc.contributor.authorGALAN, P.
dc.contributor.authorHERCBERG, S.
dc.contributor.authorMATHIESON, I.
dc.contributor.authorREDON, R.
dc.contributor.authorGENIN, E.
dc.contributor.authorDINA, C.
dc.date.accessioned2021-02-16T13:38:54Z
dc.date.available2021-02-16T13:38:54Z
dc.date.issued2020
dc.identifier.issn1476-5438 (Electronic) 1018-4813 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26254
dc.description.abstractEnThe study of the genetic structure of different countries within Europe has provided significant insights into their demographic history and population structure. Although France occupies a particular location at the western part of Europe and at the crossroads of migration routes, few population genetic studies have been conducted so far with genome-wide data. In this study, we analyzed SNP-chip genetic data from 2184 individuals born in France who were enrolled in two independent population cohorts. Using FineSTRUCTURE, six different genetic clusters of individuals were found that were very consistent between the two cohorts. These clusters correspond closely to geographic, historical, and linguistic divisions of France, and contain different proportions of ancestry from Stone and Bronze Age populations. By modeling the relationship between genetics and geography using EEMS, we were able to detect gene flow barriers that are similar across the two cohorts and correspond to major rivers and mountain ranges. Estimations of effective population sizes also revealed very similar patterns in both cohorts with a rapid increase of effective population sizes over the last 150 generations similar to other European countries. A marked bottleneck is also consistently seen in the two datasets starting in the 14th century when the Black Death raged in Europe. In conclusion, by performing the first exhaustive study of the genetic structure of France, we fill a gap in genetic studies of Europe that will be useful to medical geneticists, historians, and archeologists.
dc.language.isoENen_US
dc.subjectSEPIA
dc.subjectHEALTHY
dc.title.enThe genetic history of France
dc.title.alternativeEur J Hum Geneten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41431-020-0584-1en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32042083en_US
bordeaux.journalEuropean Journal of Human Geneticsen_US
bordeaux.page853-865en_US
bordeaux.volume28en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSEPIAen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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