Afficher la notice abrégée

Risk of bradyarrhythmia related to ticagrelor: a systematic review and meta-analysis

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPUJADE, Iris
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPERINO, Justine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMATHIEU, Clement
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorARNAUD, Mickael
dc.contributor.authorRASCHI, E.
dc.contributor.authorGATTI, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBEZIN, Julien
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSALVO, Francesco
dc.date.accessioned2021-02-12T15:19:55Z
dc.date.available2021-02-12T15:19:55Z
dc.date.issued2020
dc.identifier.issn1043-6618en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26235
dc.description.abstractEnContext Ticagrelor was related to bradycardia in DISPERSE-II trial. This risk has been integrated into the European risk-management plan, and its use is warned in at-risk patients. Nevertheless, this risk was not systematically assessed nor measured. Objectives To estimate the risk of bradyarrhythmia associated with ticagrelor. Study design Systematic review and meta-analysis. Data-source MEDLINE, Scopus, Cochrane Central Register of Controlled Trials, ISI web of Science, clinicaltrial.gov, clinicaltrialsregister.eu. Study selection Randomized controlled trials (RCTs) and observational studies in patients treated with ticagrelor or comparator(s). Meta-analysis Risk of bias in each RCT was assessed using Cochrane tool. Relative Risks (RR) with 95 % confidence intervals (95 %CI) were calculated for each RCT, and pooled using fixed-effect or random-effects models, when appropriate. Subgroup and sensitivity analyses were performed. A potential publication bias was searched. Results Among 82 eligible studies, event data were missing for 56 studies, due to detected reporting bias (i.e. inability to confirm zero events). Fifteen RCTs were selected and the combined RR of bradyarrhythmia was 1.15 (95 %CI 1.05−1.26), and 1.29 (1.02−1.65) for severe bradyarrhythmia. The risk appeared to be dose dependent. Restricting the analysis only to RCTs performed in patients without previous bradyarrhythmia resulted in a non-increased risk. Conclusion This meta-analysis confirmed the risk of bradyarrhythmia or severe bradyarrhythmia related to ticagrelor, and its use in patients without previous bradycardia was effective in preventing it. The evidence coming from this meta-analysis was low to moderate due to missing outcome in 2/3 of eligible studies. Waiting for access to these data, the use of ticagrelor in patients with risk factors of bradycardias should be avoided.
dc.language.isoENen_US
dc.subjectPharmacoEpi-Drugs
dc.title.enRisk of bradyarrhythmia related to ticagrelor: a systematic review and meta-analysis
dc.title.alternativePharmacol Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.phrs.2020.105089en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32687950en_US
bordeaux.journalPharmacological Researchen_US
bordeaux.page105089en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamPharmacoEpi-Drugsen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03140229
hal.version1
hal.date.transferred2021-02-12T15:19:59Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Pharmacological%20Research&rft.date=2020&rft.spage=105089&rft.epage=105089&rft.eissn=1043-6618&rft.issn=1043-6618&rft.au=PUJADE,%20Iris&PERINO,%20Justine&MATHIEU,%20Clement&ARNAUD,%20Mickael&RASCHI,%20E.&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée