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Serum fructosamine predicts macrosomia in well-controlled hyperglycaemic pregnant women: an observational cross-sectional study

dc.rights.licenseopenen_US
dc.contributor.authorPOUPON, P.
dc.contributor.authorFOUSSARD, N.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOUGNARD-GREGOIRE, Audrey
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAJAOBELINA, Kalina
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELCOURT, Cecile
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLAMIREAU, Thierry
dc.contributor.authorHAISSAGUERRE, M.
dc.contributor.authorBLANCO, L.
dc.contributor.authorALEXANDRE, L.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOHAMMEDI, Kamel
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRIGALLEAU, Vincent
IDREF: 069788146
dc.date.accessioned2021-02-11T15:20:56Z
dc.date.available2021-02-11T15:20:56Z
dc.date.issued2020
dc.identifier.issn1878-1780 (Electronic) 1262-3636 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26225
dc.description.abstractEnAim While serum fructosamine may be a good marker of glucose control in pregnant women with diabetes, its relationship with macrosomia is still uncertain. Methods In 130 hyperglycaemic women with singleton pregnancies (117 gestational diabetes mellitus, 13 pregestational diabetes), serum fructosamine and HbA1c levels were measured at 25 ± 7 weeks of gestation. Levels in mothers of infants with and without macrosomic newborns (birth weight > 4000 g and/or large-for-gestational-age birth weight > 90th percentile) were compared using logistic regression analysis adjusted for macrosomia risk factors. Results These 130 pregnant women were 33 ± 5 years old; their BMI before pregnancy was 27.7 ± 6.9 kg/m2, and they gained 7.5 ± 5.1 kg during the first 6 months of gestation. Glucose control was good according to HbA1c levels (5.3 ± 0.3%; 34 ± 2 mmol/mol), yet 17/130 (13%) newborns had macrosomia: 3900 ± 227 g vs 3057 ± 512 g (P < 0.001) in the others. These mothers were older and had higher parity, whereas their BMI scores before pregnancy and gestational weight gains did not differ. Fructosamine levels were also higher at 221 ± 40 μmol/L vs 192 ± 22 μmol/l (P < 0.001), respectively, and remained significant even after adjusting for maternal age, BMI, parity, type of diabetes, antecedents of macrosomia and excessive gestational weight gain. By contrast, HbA1c did not differ between the two groups. In fact, nearly two-thirds (64.7%) of the mothers of macrosomic newborns had fructosamine levels > 200 μmol/l vs 31.9% of mothers with non-macrosomic newborns (P < 0.05). Conclusion High fructosamine levels are associated with macrosomia in the newborns of well-controlled hyperglycaemic pregnant women.
dc.language.isoENen_US
dc.subjectLEHA
dc.title.enSerum fructosamine predicts macrosomia in well-controlled hyperglycaemic pregnant women: an observational cross-sectional study
dc.title.alternativeDiabetes Metaben_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.diabet.2019.07.003en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31325500en_US
bordeaux.journalDiabetes and Metabolismen_US
bordeaux.page219-222en_US
bordeaux.volume46en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03139029
hal.version1
hal.date.transferred2021-02-11T15:20:59Z
hal.exporttrue
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