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Use of benzodiazepines and z-drugs not compliant with guidelines and associated factors: a population-based study

dc.rights.licenseopenen_US
dc.contributor.authorPANES, A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPARIENTE, Antoine
IDREF: 13395711X
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBENARD-LARIBIERE, Anne
dc.contributor.authorLASSALLE, Regis
dc.contributor.authorDUREAU-POURNIN, Caroline
dc.contributor.authorLORRAIN, Simon
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDAUBECH-TOURNIER, Marie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFOURRIER-REGLAT, Annie
dc.date.accessioned2021-02-09T13:54:41Z
dc.date.available2021-02-09T13:54:41Z
dc.date.issued2020
dc.identifier.issn1433-8491 (Electronic) 0940-1334 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26194
dc.description.abstractEnBenzodiazepines and z-drugs are primarily indicated for the treatment of sleep disorders and anxiety symptoms. Their frequent long-term use contrasts with the international guidelines that limit treatment duration to a maximum of 4 weeks. The objective of this study was to assess the frequency of their use that was not in accordance with guidelines in the French general population between 2007 and 2012 and associated characteristics. A cohort of 67,550 benzodiazepine new users was set up in an exhaustive database for health-care reimbursements and representative of the French population. Benzodiazepine use not in accordance with guidelines was defined as the concomitant dispensation of several benzodiazepines, the dispensation of treatment over a period longer than recommended, or a new dispensing within the 2 months following the end of a previous treatment of maximum recommended duration, considering that French recommendations distinguish between hypnotic (4 weeks) and anxiolytic benzodiazepines (12 weeks). Benzodiazepine use not in accordance with guidelines was high, in about 30% of new hypnotic users and 20% of new anxiolytic users. Its frequency was stable over the study period. Associated characteristics were similar for new hypnotic or anxiolytic users, i.e.. older age, treatment initiation by a psychiatrist, presence of a chronic disease, hospitalization, or another psychotropic treatment. These findings provide a solid basis for establishing a public health policy to reduce benzodiazepine use not compliant with guidelines. They should be further explored in patients most at risk in the present study, e.g., patients treated by a psychiatrist.
dc.language.isoENen_US
dc.subjectPharmacoEpi-Drugs
dc.title.enUse of benzodiazepines and z-drugs not compliant with guidelines and associated factors: a population-based study
dc.title.alternativeEur Arch Psychiatry Clin Neuroscien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00406-018-0966-3en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30539229en_US
bordeaux.journalEuropean Archives of Psychiatry and Clinical Neuroscienceen_US
bordeaux.page3-10en_US
bordeaux.volume270en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamPharmacoEpi-Drugsen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03136115
hal.version1
hal.date.transferred2021-02-09T13:54:47Z
hal.exporttrue
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