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Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome

dc.rights.licenseopenen_US
dc.contributor.authorNADAL, L.
dc.contributor.authorCOUPE, P.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorMANJON, J. V.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAMIEVA, Helene
dc.contributor.authorTISON, F.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529
IDREF: 058586105
dc.contributor.authorCATHELINE, G.
dc.contributor.authorPLANCHE, V.
dc.date.accessioned2021-02-08T13:13:31Z
dc.date.available2021-02-08T13:13:31Z
dc.date.issued2020
dc.identifier.issn0197-4580en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26176
dc.description.abstractEnSeveral studies have investigated the differential vulnerability of hippocampal subfields during aging and Alzheimer's disease (AD). Results were often contradictory, mainly because these works were based on concatenations of cross-sectional measures in cohorts with different ages or stages of AD, in the absence of a longitudinal design. Here, we investigated 327 participants from a population-based cohort of nondemented older adults with a 14-year clinical follow-up. MRI at baseline and 4 years later were assessed to measure the annualized rates of hippocampal subfields atrophy in each participant using an automatic segmentation pipeline with subsequent quality control. On the one hand, CA4 dentate gyrus was significantly more affected than the other subfields in the whole population (CA1-3: −0.68%/year; subiculum: −0.99%/year; and CA4-DG: −1.39%/year; p < 0.0001). On the other hand, the annualized rate of CA1-3 atrophy was associated with an increased risk of developing Alzheimer's clinical syndrome over time, independently of age, gender, educational level, and ApoE4 genotype (HR = 2.0; CI 95% 1.4–3.0). These results illustrate the natural history of hippocampal subfields atrophy during aging and AD by showing that the dentate gyrus is the most vulnerable subfield to the effects of aging while the cornu-ammonis is the primary target of AD pathophysiological processes, years before symptom onset.
dc.language.isoENen_US
dc.subjectSEPIA
dc.subjectLEHA
dc.title.enDifferential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome
dc.title.alternativeNeurobiol Agingen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neurobiolaging.2020.01.011en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32107063en_US
bordeaux.journalNeurobiology of Agingen_US
bordeaux.page75-83en_US
bordeaux.volume90en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSEPIAen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Neurobiology%20of%20Aging&amp;rft.date=2020&amp;rft.volume=90&amp;rft.spage=75-83&amp;rft.epage=75-83&amp;rft.eissn=0197-4580&amp;rft.issn=0197-4580&amp;rft.au=NADAL,%20L.&amp;COUPE,%20P.&amp;HELMER,%20Catherine&amp;MANJON,%20J.%20V.&amp;AMIEVA,%20Helene&amp;rft.genre=article


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