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Retinal vascular fractal dimension and cerebral blood flow, a pilot study

dc.rights.licenseopenen_US
dc.contributor.authorNADAL, J.
dc.contributor.authorDEVERDUN, J.
dc.contributor.authorDE CHAMPFLEUR, N. M.
dc.contributor.authorCARRIERE, I.
dc.contributor.authorCREUZOT-GARCHER, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELCOURT, Cecile
ORCID: 0000-0002-2099-0481
IDREF: 035105291
dc.contributor.authorCHIQUET, C.
dc.contributor.authorKAWASAKI, R.
dc.contributor.authorVILLAIN, M.
dc.contributor.authorRITCHIE, K.
dc.contributor.authorLE BARS, E.
dc.contributor.authorDAIEN, V.
dc.date.accessioned2021-02-08T12:52:29Z
dc.date.available2021-02-08T12:52:29Z
dc.date.issued2020
dc.identifier.issn1755-3768 (Electronic) 1755-375X (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26175
dc.description.abstractEnPurpose Ocular and brain microcirculation share embryological and histological similarities. The retinal vascular fractal dimension (FD) is a marker of retinal vascular complexity of the vascular tree. The purpose of this study was to explore the relationship between cerebral blood flow (CBF), retinal vascular FD and other retinal vascular markers. Methods Cross‐sectional analysis comprising 26 individuals ≥65 years old from the Cognitive REServe and Clinical ENDOphenotype (CRESCENDO) cohort of relative healthy older adults. Retinal vascular FD was measured from fundus photographs by using the semi‐automated Singapore Eye Vessel Assessment (SIVA) software. CBF was estimated using a 2D pulsed ASL MRI sequence. Associations between blood flow and retinal parameters were analysed using linear regression models adjusted for age and sex. Results Cerebral blood flow was positively associated with venular FD (R2 = 0.32, p = 0.03). This association was stronger in the anterior versus posterior brain territories (R2 = 0.35 [p = 0.001] versus R2 = 0.16 [p = 0.07], respectively). Global CBF was correlated with arteriolar branching angle (R2 = 0.23, p = 0.01) and tortuosity (R2 = 0.20, p = 0.02). Global CBF was not correlated with other SIVA parameters. Conclusions Retinal venular complexity summarized by the FD was associated with cerebral blood flow as well as retinal arteriolar tortuosity and branching angle. Larger prospective clinical studies are needed to confirm these results.
dc.language.isoENen_US
dc.subjectLEHA
dc.title.enRetinal vascular fractal dimension and cerebral blood flow, a pilot study
dc.title.alternativeActa Ophthalmolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/aos.14232en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31545560en_US
bordeaux.journalActa Ophthalmologicaen_US
bordeaux.pagee63-e71en_US
bordeaux.volume98en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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