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Previous dramatic reduction of HbA1c and retinopathy in Type 2 Diabetes

dc.rights.licenseopenen_US
dc.contributor.authorLARROUMET, A.
dc.contributor.authorRIGO, M.
dc.contributor.authorLECOCQ, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELYFER, Marie-Noelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorKOROBELNIK, Jean-Francois
ORCID: 0000-0002-4438-9535
IDREF: 028739272
dc.contributor.authorMONLUN, M.
dc.contributor.authorFOUSSARD, N.
dc.contributor.authorPOUPON, P.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBLANCO-BAILLET, Laurence
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOHAMMEDI, Kamel
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRIGALLEAU, Vincent
IDREF: 069788146
dc.date.accessioned2021-02-01T15:51:17Z
dc.date.available2021-02-01T15:51:17Z
dc.date.issued2020
dc.identifier.issn1873-460X (Electronic) 1056-8727 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26087
dc.description.abstractEnAims Does Diabetic Retinopathy (DR) relate to a previous dramatic reduction of HbA1c in Type 2 Diabetes (T2D)? Methods In patients hospitalized for T2D, we collected HbA1c values from previous years, and we defined “Rapid declinors” by a more than −3% reduction between two consecutive HbA1c, and “sustained moderate declinors” by HbA1c declining less than −3%. We analyzed the relation between DR and previous HbA1c courses, adjusted for other risk factors. Results Our 680 patients had a mean HbA1c at 8.7 ± 1.7% at admission and 8.7 ± 1.8 to 9.0 ± 2.2% during previous years (1500 HbA1C values collected), and 24% had a DR. A previous rapid decline of HbA1c occurred in 13.5% of subjects and related to DR (OR = 1.86, 95%CI:1.02–3.40), especially proliferative (OR = 2.64, 95%CI:1.02–6.80), after adjustment for age, gender, body mass index, arterial hypertension and diabetic kidney disease, blood lipids and statin treatment, duration of diabetes and mean previous HbA1c. A previous moderate reduction of HbA1c as occurred in 28.3% other subjects was not related to DR. Conclusions In subjects hospitalized for T2D, a previous rapid decline of HbA1c was related to proliferative DR, whereas a sustained moderate decline appeared to be safe.
dc.language.isoENen_US
dc.subjectLEHA
dc.title.enPrevious dramatic reduction of HbA1c and retinopathy in Type 2 Diabetes
dc.title.alternativeJ Diabetes Complicationsen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jdiacomp.2020.107604en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32360194en_US
bordeaux.journalJournal of Diabetes and its Complicationsen_US
bordeaux.page107604en_US
bordeaux.volume34en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03127813
hal.version1
hal.date.transferred2021-02-01T15:51:21Z
hal.exporttrue
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