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Long term evolution of renal function in essential hypertensive patients with no baseline proteinuria

dc.rights.licenseopenen_US
dc.contributor.authorGOSSE, P.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSEGALAS, Corentin
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorRUBIN, Sebastien
dc.contributor.authorBOULESTREAU, R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorJACQMIN-GADDA, Helene
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFFONDRE, Karen
IDREF: 183599128
dc.contributor.authorCOMBE, C.
dc.contributor.authorCREMER, A.
dc.date.accessioned2021-01-26T13:04:21Z
dc.date.available2021-01-26T13:04:21Z
dc.date.issued2020
dc.identifier.issn1476-5527 (Electronic) 0950-9240 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26015
dc.description.abstractEnData on the long term evolution of renal function in essential hypertensive patients are scarce, showing a low incidence of end stage renal diseases but without information on how the renal function evolves. Our aim is to describe the long term evolution of renal function and possible trajectories in hypertensive patients. We included patients from an ongoing cohort with essential hypertension, no proteinuria at baseline and no diabetes during follow-up and with at least two creatinine dosages 4 years apart. A long term (average 16 years) follow-up was available in 609 patients (baseline age 51.8 ± 11.1 years, 52 % male, mean office BP 156//95 mmHg). The trajectories of creatinine were modeled through a flexible latent class mixed model. The analysis identified three classes of significantly different trajectories. In the first (n = 560), there was no significant variation of creatinine over time. In the second (n = 40), there was a significant rise of creatinine (117 ± 20 vs 85 ± 17 µmol/l, p < 0.0001). The third class (n = 9) was very heterogeneous, mainly composed of outliers. Further analysis showed the nonlinearity of the evolution of creatinine in classes 2 and 3. So the model of progressive renal deterioration in essential hypertension does not fit with our results. A large majority (92%) of patients show no significant change in creatinine level with time. In the others 8%, the increase in creatinine is not progressive but conversely show one or more sudden bouts of elevation.
dc.language.isoENen_US
dc.subjectBiostatistics
dc.title.enLong term evolution of renal function in essential hypertensive patients with no baseline proteinuria
dc.title.alternativeJ Hum Hypertensen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41371-019-0245-4en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31477829en_US
bordeaux.journalJournal of Human Hypertensionen_US
bordeaux.page560-567en_US
bordeaux.volume34en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERM
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03121436
hal.version1
hal.date.transferred2021-01-26T13:04:25Z
hal.exporttrue
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