Disease progression and prognostic factors in multiple system atrophy: A prospective cohort study
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SAMIER FOUBERT, Alexandra | |
| dc.contributor.author | TRAON, A. P. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GUILLET, Florian | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LE GOFF, Melanie
ORCID: 0000-0003-2848-6287 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HELMER, Catherine | |
| dc.contributor.author | TISON, F. | |
| dc.contributor.author | RASCOL, O. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PROUST LIMA, Cecile
ORCID: 0000-0002-9884-955X IDREF: 114375747 | |
| dc.contributor.author | MEISSNER, W. G. | |
| dc.date.accessioned | 2021-01-25T14:26:19Z | |
| dc.date.available | 2021-01-25T14:26:19Z | |
| dc.date.issued | 2020 | |
| dc.identifier.issn | 1095-953X (Electronic) 0969-9961 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/25987 | |
| dc.description.abstractEn | Multiple system atrophy (MSA) is a rare neurodegenerative disease, with limited understanding of disease progression and prognostic factors. We leveraged the data of a large prospective cohort of MSA to study both clinical progression and survival and assess their determinants. All consecutive patients seen at the French Reference Centre for MSA since 2007 were included in a prospective cohort with an annual follow-up including the Unified MSA Rating Scale (UMSARS). We used joint models to evaluate the risk of death, the mean trajectory of each UMSARS subscale and to determine the potential factors. Investigated factors included gender, age at baseline, MSA subtype, diagnosis certainty, type of first symptoms and the duration between symptom onset and the first visit. Among the 261 MSA patients included in our cohort, the median duration of clinical follow-up was 2.1 years (up to 10.3 years) and the median survival was 4.0 years since the first visit. Main factors for poor survival were the progression over time of UMSARS score (I + II and IV) and the severity of orthostatic hypotension. MSA subtype had no effect on progression or survival. The UMSARS I + II score progressed faster over time in subjects with autonomic dysfunction as the initial feature and in women. Despite a faster progression, women and men had similar survival. From this large MSA cohort, we confirm the rapid progression and poor prognosis of MSA. We provide additional evidence for a negative impact of early autonomic dysfunction and the severity of orthostatic hypotension on both disease progression and survival. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject | SEPIA | |
| dc.subject | LEHA | |
| dc.subject | Biostatistics | |
| dc.title.en | Disease progression and prognostic factors in multiple system atrophy: A prospective cohort study | |
| dc.title.alternative | Neurobiol Dis | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.nbd.2020.104813 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 32087288 | en_US |
| bordeaux.journal | Neurobiology of Disease | en_US |
| bordeaux.page | 104813 | en_US |
| bordeaux.volume | 139 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | SEPIA | en_US |
| bordeaux.team | LEHA_BPH | |
| bordeaux.team | BIOSTAT_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03120476 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-01-25T14:26:24Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neurobiology%20of%20Disease&rft.date=2020&rft.volume=139&rft.spage=104813&rft.epage=104813&rft.eissn=1095-953X%20(Electronic)%200969-9961%20(Linking)&rft.issn=1095-953X%20(Electronic)%200969-9961%20(Linking)&rft.au=SAMIER%20FOUBERT,%20Alexandra&TRAON,%20A.%20P.&GUILLET,%20Florian&LE%20GOFF,%20Melanie&HELMER,%20Catherine&rft.genre=article |
