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Cognitive and functional changes in prediagnostic phase of Parkinson disease: A population-based study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIER FOUBERT, Alexandra
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLE GOFF, Melanie
ORCID: 0000-0003-2848-6287
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGUILLET, Florian
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST LIMA, Cecile
ORCID: 0000-0002-9884-955X
IDREF: 114375747
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorJACQMIN-GADDA, Helene
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529
IDREF: 058586105
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAMIEVA, Helene
dc.contributor.authorTISON, F.
dc.date.accessioned2021-01-25T14:17:20Z
dc.date.available2021-01-25T14:17:20Z
dc.date.issued2020
dc.identifier.issn1353-8020en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/25986
dc.description.abstractEnIntroduction Prodromal non-motor symptoms precede, often by decades, motor signs and diagnosis of Parkinson's disease. It is however still uncertain if cognitive changes belong to the spectrum of non-motor prodromal Parkinson's disease. Thanks to the very long-term follow-up of the PAQUID population-based cohort, we assessed trajectories of cognitive complaints and functioning over a 13-year period before the diagnosis of late onset Parkinson's disease. Methods This study relies on a matched nested case-control sample selected from the cohort. Of the 3777 initial subjects of the cohort, 43 developed incident Parkinson's disease over the follow-up. The mean age at diagnosis was 78.0 (standard deviation = 5.8) years and 46.5% were men. These cases were matched to 86 elderly control subjects. Scores of different cognitive domains, daily function, and depressive symptoms were described throughout the follow-up using mixed-effects models. Results No significant global cognitive decline preceded the diagnosis of late onset Parkinson's disease. However, psychomotor speed appeared significantly slower 2 years before the diagnosis and depressive symptoms 12 years before. Global score of instrumental activities of daily living became altered 2–3 years preceding the diagnosis of late onset Parkinson's disease, including the use of public transportation that was altered ten years before the diagnosis. Conclusion In late onset Parkinson's disease, while global cognitive functions seem preserved, psychomotor speed starts to decline 2 years before the diagnosis and activities of daily living are also impacted. Depressive symptoms appear very early in the prediagnosic phase.
dc.language.isoENen_US
dc.subjectSEPIA
dc.subjectLEHA
dc.subjectBiostatistics
dc.title.enCognitive and functional changes in prediagnostic phase of Parkinson disease: A population-based study
dc.title.alternativeParkinsonism Relat Disorden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.parkreldis.2020.08.022en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32862017en_US
bordeaux.journalParkinsonism and Related Disordersen_US
bordeaux.page40-46en_US
bordeaux.volume79en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSEPIAen_US
bordeaux.teamLEHA_BPH
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03120461
hal.version1
hal.date.transferred2021-01-25T14:17:24Z
hal.exporttrue
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