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Increased Incidence of Intracranial Meningiomas in Patients With Acromegaly

dc.rights.licenseopenen_US
dc.contributor.authorENGELHARDT, J.
dc.contributor.authorNUNES, M. L.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPOUCHIEU, Camille
dc.contributor.authorFERRIERE, A.
dc.contributor.authorSAN-GALLI, F.
dc.contributor.authorGIMBERT, E.
dc.contributor.authorVIGNES, J. R.
dc.contributor.authorLAURENT, F.
dc.contributor.authorBERGE, J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBALDI, Isabelle
dc.contributor.authorTABARIN, A.
dc.contributor.authorLOISEAU, H.
dc.date.accessioned2021-01-25T10:06:22Z
dc.date.available2021-01-25T10:06:22Z
dc.date.issued2020
dc.identifier.issn1524-4040 (Electronic) 0148-396X (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/25973
dc.description.abstractEnBACKGROUND An increased incidence of various neoplasms has been described in patients with acromegaly, and there is evidence to suggest that growth factors are risk factors for the development of meningiomas. OBJECTIVE To study if patients with acromegaly are more at risk for developing intracranial meningiomas. METHODS We conducted an observational study on 221 consecutive acromegalic patients recruited between January 1, 2000 and December 31, 2015, and 357 consecutive patients with a nonsomatotropic pituitary adenoma recruited between March 1, 2015 and December 31, 2016, in our institution. Patients underwent a gadolinium-enhanced 3D T1 brain magnetic resonance imaging to look for meningiomas. The proportion of meningiomas was compared between the 2 groups, and the standardized incidence ratio (SIR) was computed from the incidence rates of meningiomas observed in the population of acromegalic patients and compared to that of the general population given by the local registry of central nervous system tumors. RESULTS Patients with acromegaly had a significant risk for developing intracranial meningiomas as compared to patients without acromegaly (7.7% vs 2.2%, P = .005, OR = 3.45 [1.46; 8.15]). There was a significant increased incidence of intracranial meningiomas in patients with acromegaly (SIR = 126 [25; 367]) as compared to the general population. CONCLUSION Our study suggests strongly that patients with acromegaly are more at risk for developing intracranial meningiomas.
dc.language.isoENen_US
dc.subjectEPICENE
dc.title.enIncreased Incidence of Intracranial Meningiomas in Patients With Acromegaly
dc.title.alternativeNeurosurgeryen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/neuros/nyz438en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.journalNeurosurgeryen_US
bordeaux.page639-646en_US
bordeaux.volume87en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03119900
hal.version1
hal.date.transferred2021-01-25T10:06:26Z
hal.exporttrue
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