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Age-related change in episodic memory: role of functional and structural connectivity between the ventral posterior cingulate and the parietal cortex

dc.rights.licenseopenen_US
dc.contributor.authorEDDE, M.
dc.contributor.authorDILHARREGUY, B.
dc.contributor.authorTHEAUD, G.
dc.contributor.authorCHANRAUD, S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529
IDREF: 058586105
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAMIEVA, Helene
dc.contributor.authorALLARD, M.
dc.contributor.authorDESCOTEAUX, M.
dc.contributor.authorCATHELINE, G.
dc.date.accessioned2021-01-22T14:55:35Z
dc.date.available2021-01-22T14:55:35Z
dc.date.issued2020
dc.identifier.issn1863-2661 (Electronic) 1863-2653 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/25964
dc.description.abstractEnWhile the neural correlates of age-related episodic memory decline have been extensively studied, the precise involvement of the Posterior Cingulate Cortex (PCC) and posterior parietal cortex (the precuneus and the angular gyrus), remains unclear. The present study examined functional and structural neural correlates of age-related episodic memory change assessed over 12 years in 120 older adults (range 76–90 years). Episodic memory performance was measured using the Free and Cued Selective Reminding Test (FCSRT); functional connectivity metrics were computed from resting-state fMRI images and structural connectivity metrics were assessed through microstructural properties of reconstructed tract using a native space pipeline. We found that FCSRT change was significantly associated with the functional connectivity between the ventral PCC and three parietal regions, the ventral superior, the inferior part of the precuneus, and the rostro dorsal part of the angular gyrus. This association was independent of hippocampal volume. In addition, we found the that change in FCSRT scores was associated with fractional anisotropy of the tract connecting the ventral PCC and the ventral superior part of the precuneus. Change in episodic memory in aging was therefore related to a combination of high functional connectivity and low structural connectivity between the ventral PCC and the ventral superior part of the precuneus.
dc.language.isoENen_US
dc.subjectLEHA
dc.subjectSEPIA
dc.title.enAge-related change in episodic memory: role of functional and structural connectivity between the ventral posterior cingulate and the parietal cortex
dc.title.alternativeBrain Struct Functen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00429-020-02121-7en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32728934en_US
bordeaux.journalBrain Structure and Functionen_US
bordeaux.page2203-2218en_US
bordeaux.volume225en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.teamSEPIAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03118841
hal.version1
hal.date.transferred2021-01-22T14:55:38Z
hal.exporttrue
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