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Subjective cognitive and non-cognitive complaints and brain MRI biomarkers in the MEMENTO cohort

dc.rights.licenseopenen_US
dc.contributor.authorDAUPHINOT, V.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBOUTELOUP, Vincent
dc.contributor.authorMANGIN, J. F.
dc.contributor.authorVELLAS, B.
dc.contributor.authorPASQUIER, F.
dc.contributor.authorBLANC, F.
dc.contributor.authorHANON, O.
dc.contributor.authorGABELLE, A.
dc.contributor.authorANNWEILER, C.
dc.contributor.authorDAVID, R.
dc.contributor.authorPLANCHE, V.
dc.contributor.authorGODEFROY, O.
dc.contributor.authorRIVASSEAU-JONVEAUX, T.
dc.contributor.authorCHUPIN, M.
dc.contributor.authorFISCHER, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHENE, Genevieve
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
dc.contributor.authorKROLAK-SALMON, P.
dc.date.accessioned2021-01-21T09:23:34Z
dc.date.available2021-01-21T09:23:34Z
dc.date.issued2020
dc.identifier.issn2352-8729 (Print) 2352-8729en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/25930
dc.description.abstractEnIntroduction Subjective cognitive complaints may be a signature of preclinical stage Alzheimer's disease. However, the link between subjective cognitive and non‐cognitive complaints and brain alterations remains unclear. Methods The relationship between cognitive and non‐cognitive complaints and brain biomarkers, measured by structural magnetic resonance imaging, was investigated in 2056 participants of the MEMENTO cohort of outpatients, who were dementia‐free at baseline. We assessed whether the cognitive status at inclusion or the presence of the apolipoprotein E gene variant (APOE) ε4 could modulate the association between the intensity of complaints and brain lesions. Results Smaller hippocampal volume was associated with higher memory complaints and discomfort in daily life. In APOE ε4 carriers, smaller whole‐brain white matter and gray matter volumes and gyrification indices in several regions of interest of the parietal and temporal lobes, in the entorhinal and the para‐hippocampal gyrus, were associated with higher memory complaint score. Conclusions The intensity of subjective complaints in not only memory but discomfort in daily life was associated with brain degeneration markers. The presence of APOE ε4 modulated the relationships between subjective memory complaints and brain alterations.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectVINTAGE
dc.subjectMORPH3Eus
dc.title.enSubjective cognitive and non-cognitive complaints and brain MRI biomarkers in the MEMENTO cohort
dc.title.alternativeAlzheimers Dement (Amst)en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/dad2.12051en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32647745en_US
bordeaux.journalAlzheimers Dement (Amst)en_US
bordeaux.pagee12051en_US
bordeaux.volume12en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamVINTAGEen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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