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Orthostatic hypotension: a marker of blood pressure variability and arterial stiffness: a cross-sectional study on an elderly population: the 3-City study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCREMER, Antoine
dc.contributor.authorBOUTOUYRIE, P.
dc.contributor.authorLAURENT, Stéphane
dc.contributor.authorGOSSE, P.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
IDREF: 69829209
dc.date.accessioned2021-01-21T09:02:43Z
dc.date.available2021-01-21T09:02:43Z
dc.date.issued2020
dc.identifier.issn1473-5598 (Electronic) 0263-6352 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/25926
dc.description.abstractEnBackground: Orthostatic hypotension, blood pressure (BP) variability, and arterial stiffness are three markers of cardiovascular risk beyond the average BP. However, the relationships between these three parameters are not well known. Aim: To examine the relationships between orthostatic hypotension, BP variability, and arterial stiffness. Methods and results: In the Three-City study, a sample of 1151 elderly participants (mean age = 80 ± 3 years) was screened for orthostatic hypotension, undertook home BP and pulse wave velocity (PWV) measurements. We performed logistic regression analyses to look at the associations between orthostatic hypotension and both day-to-day (D-to-D) BP variability quartiles and PWV quartiles. Orthostatic hypotension was detected in 210 participants who were more likely to be hypertensive, exhibit higher BP variability and have increased arterial stiffness. In the multivariate logistic regression analysis, the frequency of orthostatic hypotension increased by 20% with every quartile of D-to-D SBP variability and by 20% with every quartile of PWV. PWV and D-to-D BP variability were not associated. In stratified analysis, the use of beta-blocker changes these relationships: orthostatic hypotension was not associated to PWV anymore but its association with D-to-D SBP variability was apparently stronger. Conclusion: In this large sample of elderly individuals, orthostatic hypotension was independently associated with both BP variability and PWV. BP variability being more indicative of a baroreflex dysfunction and PWV being a marker of vascular ageing, these two components would participate to the orthostatic hypotension mechanisms.
dc.language.isoENen_US
dc.subjectVINTAGE
dc.subjectHEALTHY
dc.title.enOrthostatic hypotension: a marker of blood pressure variability and arterial stiffness: a cross-sectional study on an elderly population: the 3-City study
dc.title.alternativeJournal of Hypertensionen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/HJH.0000000000002374en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32371800en_US
bordeaux.journalJournal of Hypertensionen_US
bordeaux.page1103-1109en_US
bordeaux.volume38en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamVINTAGEen_US
bordeaux.teamHEALTHYen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03167621
hal.version1
hal.date.transferred2024-06-01T08:14:23Z
hal.exporttrue
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