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International epidemiology databases to evaluate AIDS (IeDEA) in sub-Saharan Africa, 2012-2019

dc.rights.licenseopenen_US
dc.contributor.authorCHAMMARTIN, F.
dc.contributor.authorDAO OSTINELLI, C. H.
dc.contributor.authorANASTOS, K.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorJAQUET, Antoine
dc.contributor.authorBRAZIER, E.
dc.contributor.authorBROWN, S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDABIS, Francois
dc.contributor.authorDAVIES, M. A.
dc.contributor.authorDUDA, S. N.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMALATESTE, Karen
dc.contributor.authorNASH, D.
dc.contributor.authorWOOLS-KALOUSTIAN, K.
dc.contributor.authorVON GROOTE, P. M.
dc.contributor.authorEGGER, M.
dc.date.accessioned2021-01-19T10:21:12Z
dc.date.available2021-01-19T10:21:12Z
dc.date.issued2020
dc.identifier.issn2044-6055en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/25868
dc.description.abstractEnPurpose The objectives of the International epidemiology databases to evaluate AIDS (IeDEA) are to (i) evaluate the delivery of combination antiretroviral therapy (ART) in children, adolescents and adults in sub-Saharan Africa, (ii) to describe ART regimen effectiveness, durability and tolerability, (iii) to examine HIV-related comorbidities and coinfections and (iv) to examine the pregnancy-related and HIV-related outcomes of women on ART and their infants exposed to HIV or ART in utero or via breast milk. Participants IeDEA is organised in four regions (Central, East, Southern and West Africa), with 240 treatment and care sites, six data centres at African, European and US universities, and almost 1.4 million children, adolescents and adult people living with HIV (PLWHIV) enrolled. Findings to date The data include socio-demographic characteristics, clinical outcomes, opportunistic events, treatment regimens, clinic visits and laboratory measurements. They have been used to analyse outcomes in PLWHIV-1 or PLWHIV-2 who initiate ART, including determinants of mortality, of switching to second-line and third-line ART, drug resistance, loss to follow-up and the immunological and virological response to different ART regimens. Programme-level estimates of mortality have been corrected for loss to follow-up. We examined the impact of coinfection with hepatitis B and C, and the epidemiology of different cancers and of (multidrug resistant) tuberculosis, renal disease and of mental illness. The adoption of ‘Treat All’, making ART available to all PLWHIV regardless of CD4+ cell count or clinical stage was another important research topic. Future plans IeDEA has formulated several research priorities for the ‘Treat All’ era in sub-Saharan Africa. It recently obtained funding to set up sentinel sites where additional data are prospectively collected on cardiometabolic risks factors as well as mental health and liver diseases, and is planning to create a drug resistance database.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectIDLIC
dc.title.enInternational epidemiology databases to evaluate AIDS (IeDEA) in sub-Saharan Africa, 2012-2019
dc.title.alternativeBMJ Openen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/bmjopen-2019-035246en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32414825en_US
bordeaux.journalBMJ Openen_US
bordeaux.pagee035246en_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamIDLICen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03114770
hal.version1
hal.date.transferred2021-01-19T10:21:18Z
hal.exporttrue
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